Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation
Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W. Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation. International Journal Of Biological Sciences 2024, 20: 2994-3007. PMID: 38904008, PMCID: PMC11186356, DOI: 10.7150/ijbs.92802.Peer-Reviewed Original ResearchConceptsCell-free fat extractToll-like receptorsChondrocyte viabilityMacrophage polarizationOsteoarthritis rat modelChondrocyte necrosisRegulating macrophage polarizationAnnexin A5Pro-inflammatory mediator releaseCartilage damageInhibiting M1 macrophage polarizationChondrocytesM1 macrophage polarizationPain symptomsTherapeutic optionsMediator releaseRat modelTLR4 expressionMacrophage regulationProduction of reactive oxygen speciesIntra-articular administrationHistological analysisManagement of OAPolarizationAnxA5