Wei Zheng
Associate Research ScientistAbout
Research
Publications
2026
A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis
Chang X, Mariapun S, Li M, Wang L, Ho P, Khng A, Muir K, Lophatananon A, Aronson K, Murphy R, Kwong A, Au C, Kim S, Park S, Stram D, Wu A, Teo S, Yip C, Tai N, Investigators M, John E, Kurian A, Iwasaki M, Yamaji T, Choi J, Kang D, Shu X, Zheng W, Hartman M, Tan E, Tan V, Lim G, Bolla M, Dunning A, Dennis J, Wang Q, Naven M, Easton D, Consortium S, Dorajoo R, Ho W, Li J. A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis. Human Molecular Genetics 2026, 35: ddag015. PMID: 41871294, PMCID: PMC13017919, DOI: 10.1093/hmg/ddag015.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosis Regulatory ProteinsAsian PeopleBreast NeoplasmsCase-Control StudiesEstrogen Receptor alphaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 2Receptors, ProgesteroneTrans-ActivatorsConceptsGenome-wide association studiesReference panelBreast Cancer Association ConsortiumAssociation studiesBreast cancer riskImputation reference panelAsian populationsCase-control analysisCancer riskVariant discoveryCandidate lociImputation panelAssociation signalsCase-controlRare allelesVariant detectionGenetic variantsRare variantsBreast cancerEuropean populationsCancer datasetsBreastBreast cancer datasetVariantsSG10Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease
Gao P, Pavlinov I, Xu M, Chen C, Vasquez D, Zhang Q, Ye Y, Martinez-Sobrido L, Zheng W, Shen M. Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease. Molecules 2026, 31: 1043. PMID: 41900142, DOI: 10.3390/molecules31061043.Peer-Reviewed Original ResearchConceptsMolecular docking studiesMolecular dynamics simulationsSARS-CoV-2 inhibitorsChemically diverse scaffoldsDual-target inhibitionIn-house collectionEvolution of severe acute respiratory syndrome coronavirus 2Protease active siteDiverse scaffoldsDocking studiesBinding modeSARS-CoV-2 entryNovel hitsDynamics simulationsActive siteInhibitors of SARS-CoV-2 entryHost interactionsModerate potencyGraph convolutional networkSARS-CoV-2Sulfate interactionAntiviral strategiesViral mechanismsConvolutional networkProteaseCirculating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study
Zheng Y, Yang J, Gupta D, Herrington D, Yu B, Nguyen N, Pinto R, Tzoulaki I, Cai H, Cai Q, Lipworth L, Shu X, Zheng W, Yu D. Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study. PLOS Medicine 2026, 23: e1004750. PMID: 41843497, PMCID: PMC12994840, DOI: 10.1371/journal.pmed.1004750.Peer-Reviewed Original ResearchConceptsIncident coronary heart diseaseBody mass indexCoronary heart diseaseFollow-up timeOdds ratioMulti-Ethnic StudyShanghai Women's Health StudyHeart diseaseShanghai Men's Health StudyMetabolic disease historyHealth StudyAssociated with incident coronary heart diseaseMicrobial metabolitesWomen's Health StudySouthern Community Cohort StudyPlasma metabolite profilesCoronary heart disease developmentMen's Health StudyRisk of coronary heart diseaseConditional logistic regressionHuman cardiometabolic healthMulti-Ethnic Study of AtherosclerosisCommunity Cohort StudyGut microbial metabolismCoronary heart disease diagnosisHigh-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression
Sahin G, Guyett P, Xu K, Kouznetsova J, Zheng W, Hendrickson M. High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression. SLAS DISCOVERY 2026, 40: 100303. PMID: 41839426, DOI: 10.1016/j.slasd.2026.100303.Peer-Reviewed Original ResearchInduced pluripotent stem cellsSpinal motor neuronsTGF-b signalingMotor neuronsAmyotrophic lateral sclerosisTGF-bHigh-throughput screeningLight chain expressionFDA-approved treatmentIn vivo drug metabolismAmyotrophic lateral sclerosis patientsIPSC-derived motor neuronsPluripotent stem cellsNeurofilament light chainIPSC-derived neuronsChain expressionSubunit expressionSpinal cordNF-L expressionCell-based reporter systemALS patientsStem cellsDrug metabolismPathology of amyotrophic lateral sclerosisNeuronsEstrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies.
Yuan F, Shu X, Long J, Huang W, Lipworth L, Xu X, Khankari N, Watts E, Tao R, Cai H, Moore S, Zheng W. Estrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies. Cancer Prevention Research 2026, of1-of10. PMID: 41808586, DOI: 10.1158/1940-6207.capr-25-0382.Peer-Reviewed Original ResearchRisk of postmenopausal breastLifestyle scoreAssociated with lower riskRisk of breastPostmenopausal breastLifestyle patternsShanghai Women's Health StudyEstrogen metabolitesHazard ratioOvarian Screening TrialLower risk of breastWomen's Health StudyConfidence intervalsOvarian cancerEndometrial cancerParent estrogensEtiology of hormone-related cancersProspective cohort studyER-negative breast cancerEstrogen receptor (ER)-positiveLow riskCox proportional hazards modelsHormone-related cancersProportional hazards modelHealth StudyGeneration and characterization of induced pluripotent stem cell (iPSC) lines from patients affected with Tay-Sachs and Sandhoff disease
Jovanovic V, Chen C, Toro C, Hurd K, Zou J, Tifft C, Zheng W, Henderson M, Marugan J, Tristan C. Generation and characterization of induced pluripotent stem cell (iPSC) lines from patients affected with Tay-Sachs and Sandhoff disease. Stem Cell Research 2026, 92: 103949. PMID: 41795546, DOI: 10.1016/j.scr.2026.103949.Peer-Reviewed Original ResearchConceptsHEXB geneTay-SachsBeta subunitLysosomal storage disease modelsSandhoff diseaseHeterozygous mutationsTay-Sachs patientsIPSC linesComplex heterozygous mutationHEXA geneSandhoff patientsTherapeutic drug developmentPluripotent stem cellsLate-onset diseaseGenesMutationsHEXBGenetic mutationsLysosomal hexosaminidasesSandhoffPatientsStem cellsDrug developmentDisease modelsDiseaseLonger-term aspirin use and subsequent ovarian cancer risk in the Ovarian Cancer Cohort Consortium
Hurwitz L, O’Brien K, Townsend M, Reid B, Fridley B, Fan W, Schabath M, Bodelon C, Chan A, Fortner R, Håkansson N, Harris H, Lacey J, Liao L, Merritt M, Patel A, Poynter J, Robien K, Sandler D, Wentzensen N, Wolk A, Zheng W, Tworoger S, Trabert B. Longer-term aspirin use and subsequent ovarian cancer risk in the Ovarian Cancer Cohort Consortium. International Journal Of Epidemiology 2026, 55: dyag019. PMID: 41740062, PMCID: PMC13037452, DOI: 10.1093/ije/dyag019.Peer-Reviewed Original ResearchConceptsOvarian cancer riskOvarian cancer risk factorsOvarian Cancer Cohort ConsortiumFrequent aspirin useCancer risk factorsLow-dose aspirin useCancer riskAspirin useCohort ConsortiumAssociated with lower ovarian cancer riskRisk factorsLower ovarian cancer riskRisk of ovarian cancerOvarian cancerCancer primary preventionLong-term useAssociated with ovarian cancerProspective cohort studyLow-dose aspirinPrimary preventionSelf-ReportCohort studyLogistic regressionObservational studyRisk reductionDemographic and Clinicopathologic Factors Associated With Colorectal Adenoma Recurrence
Awan U, Song Q, Ciombor K, Toriola A, Choi J, Su T, Shu X, Idrees K, Washington K, Zheng W, Wen W, Yin Z, Guo X. Demographic and Clinicopathologic Factors Associated With Colorectal Adenoma Recurrence. JAMA Network Open 2026, 9: e2556853. PMID: 41637071, PMCID: PMC12873766, DOI: 10.1001/jamanetworkopen.2025.56853.Peer-Reviewed Original ResearchConceptsAdenoma recurrenceFamily history of colorectal cancerAdenoma featuresHistory of colorectal cancerFamily historyHigh-risk adenomasColorectal adenoma recurrenceDemographic factorsAssociation of demographic factorsColorectal cancerAssociation of exposureAdenoma characteristicsFollow-up timeVillous histologySurveillance intervalsRetrospective cohort studyColonoscopic polypectomySurveillance guidelinesMain OutcomesTertiary medical centerExposure associationsPersonal careRecurrence riskCohort studyPrimary outcomeThree-Year Update of a Randomized Phase IIb Study of the Individualized Neoantigen Therapy Intismeran Autogene (mRNA-4157, V940) Plus Pembrolizumab Versus Pembrolizumab in Resected Melanoma
Carlino M, Khattak A, Meniawy T, Ansstas G, Taylor M, Kim K, McKean M, Long G, Sullivan R, Faries M, Tran T, Cowey C, Pecora A, Shaheen M, Segar J, Medina T, Atkinson V, Gibney G, Luke J, Thomas S, Buchbinder E, Hamid O, Weber J, Mooradian M, Howle J, Khan A, Huang M, Healy J, Morrissey M, Feldman I, Sehgal V, Lu M, Rao A, Zheng W, Srinivasan L, Mao H, Guo J, Zhu L, Posadas T, Brown M, Zaks T, Meehan R, Mehnert J. Three-Year Update of a Randomized Phase IIb Study of the Individualized Neoantigen Therapy Intismeran Autogene (mRNA-4157, V940) Plus Pembrolizumab Versus Pembrolizumab in Resected Melanoma. JCO Oncology Advances 2026 DOI: 10.1200/oa-25-00008.Peer-Reviewed Original ResearchDistant metastasis-free survivalRecurrence-free survivalPhase IIb studyAdverse eventsAdjuvant treatmentFollow-upHigh-risk resected melanomaImmune-related adverse eventsRandomized phase IIb studyResected high-risk melanomaProlonged recurrence-free survivalGrade 3/4 eventsHigh-risk melanomaYears of follow-upMedian Follow-UpMetastasis-free survivalPrimary analysisSecondary end pointsResected melanomaOverall survivalCutaneous melanomaPembrolizumabSafety profileNo gradeLow-gradeThe Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors
Kanetsky P, Almstrup K, Cherlin S, Cortessis V, Ferlin A, Gietema J, González‐Neira A, Grotmol T, Hamilton R, Haugen T, Kiemeney L, Kim J, Krausz C, Lessel D, Lothe R, Nead K, Nsengimana J, Poynter J, Rajpert‐DeMeyts E, Richiardi L, Schwartz S, Skotheim R, Stewart D, Turnbull C, Wiklund F, Zheng T, Nathanson K, McGlynn K, Consortium F. The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors. Andrology 2026, e70168. PMID: 41486674, PMCID: PMC12774445, DOI: 10.1111/andr.70168.Peer-Reviewed Original ResearchTesticular germ cell tumorsSequence dataGenetic informationMale germ cell developmentWhole-genome sequencing dataPhenotypic informationWhole-exome sequencing dataGenetic etiologySNP array dataGerm cell developmentSomatic cell DNAEtiology of testicular germ cell tumorsGenetic susceptibilityGenetic architectureGenomic informationChromosome segregationGerm cell tumorsRNA transcriptsPhenotypic dataSex determinationGermline DNACell developmentCell DNACell tumorsCancer Consortium
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