Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands
Wójcik S, Birol M, Rhoades E, Miranker AD, Levine ZA. Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands. Methods In Enzymology 2018, 611: 703-734. PMID: 30471705, DOI: 10.1016/bs.mie.2018.09.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug DiscoveryHumansIntrinsically Disordered ProteinsLigandsModels, MolecularNuclear Magnetic Resonance, BiomolecularProtein AggregatesProtein ConformationProteomicsSpectrometry, FluorescenceThermodynamicsConceptsSmall molecule manipulationSingle-molecule techniquesProtein ensemblesPathological functionsMolecule ligandsTractable targetsConformational flexibilityProteomeAttractive targetProteinDrug developmentExperimental approachIDPsTargetLigandsComplimentary partnersConformationBioengineeringWide range