A threonine zipper that mediates protein–protein interactions: Structure and prediction
Oi C, Treado JD, Levine ZA, Lim CS, Knecht KM, Xiong Y, O'Hern CS, Regan L. A threonine zipper that mediates protein–protein interactions: Structure and prediction. Protein Science 2018, 27: 1969-1977. PMID: 30198622, PMCID: PMC6201716, DOI: 10.1002/pro.3505.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsProtein-protein interfacesZipper structureBeta-barrel proteinsIntermonomer hydrogen bondsBarrel proteinsThr residueSide-chain dihedral anglesBiotechnological applicationsProtein interfacesMolecular dynamics simulationsDihedral angleSide-chain conformationsThrH-bondingHydrogen bondsChain conformationMD simulationsSteric constraintsDrug discoveryDynamics simulationsResiduesTargeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands
Wójcik S, Birol M, Rhoades E, Miranker AD, Levine ZA. Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands. Methods In Enzymology 2018, 611: 703-734. PMID: 30471705, DOI: 10.1016/bs.mie.2018.09.036.Peer-Reviewed Original ResearchConceptsSmall molecule manipulationSingle-molecule techniquesProtein ensemblesPathological functionsMolecule ligandsTractable targetsConformational flexibilityProteomeAttractive targetProteinDrug developmentExperimental approachIDPsTargetLigandsComplimentary partnersConformationBioengineeringWide range