Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology
Miller B, Kim S, Cao K, Mehta H, Thumaty N, Kumagai H, Iida T, McGill C, Pike C, Nurmakova K, Levine Z, Sullivan P, Yen K, Ertekin‐Taner N, Atzmon G, Barzilai N, Cohen P. Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology. Aging Cell 2024, 23: e14153. PMID: 38520065, PMCID: PMC11258485, DOI: 10.1111/acel.14153.Peer-Reviewed Original ResearchAPOE4 carriersAPOE4 alleleAmyloid beta clearanceMouse model of amyloidosisAlzheimer's diseaseAmyloid-beta pathologyIn silico analysisAmyloid-beta accumulationMitochondrial-derived peptideGenes associated with phagocytosisResistance to ADModel of amyloidosisAmyloid-betaBeta pathologyAssociated with longevitySilico analysisHumaninFactors to Alzheimer's diseaseApoE4Transcriptomic assessmentAmino acidsInfluence longevityAllelesPhagocytosisAshkenazi descent