2018
Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands
Wójcik S, Birol M, Rhoades E, Miranker AD, Levine ZA. Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands. Methods In Enzymology 2018, 611: 703-734. PMID: 30471705, DOI: 10.1016/bs.mie.2018.09.036.Peer-Reviewed Original ResearchConceptsSmall molecule manipulationSingle-molecule techniquesProtein ensemblesPathological functionsMolecule ligandsTractable targetsConformational flexibilityProteomeAttractive targetProteinDrug developmentExperimental approachIDPsTargetLigandsComplimentary partnersConformationBioengineeringWide range
2015
Regulation and aggregation of intrinsically disordered peptides
Levine ZA, Larini L, LaPointe NE, Feinstein SC, Shea JE. Regulation and aggregation of intrinsically disordered peptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 2758-2763. PMID: 25691742, PMCID: PMC4352815, DOI: 10.1073/pnas.1418155112.Peer-Reviewed Original ResearchConceptsStable native structureRole of osmolytesFragment of tauTrimethylamine N-oxideVital physiological functionsMicrotubule-associated tau proteinOsmolyte ureaAggregation propensityMicrotubule growthTau oligomerizationConformational ensemblesIDP structurePhysiological functionsNative structureCompact oligomersHelical filamentsProteinFibril formationCompact conformationNeurodegenerative diseasesTau proteinMonomer structureUnique classPeptidesN-oxide