2015
Astrocyte‐expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons
Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y. Astrocyte‐expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons. Glia 2015, 64: 48-62. PMID: 26296243, DOI: 10.1002/glia.22902.Peer-Reviewed Original ResearchConceptsFabp7 KO miceMedial prefrontal cortexMiniature excitatory postsynaptic currentsAberrant dendritic morphologyKO miceCortical neuronsDendritic morphologyNeuropsychiatric disordersWhole-cell voltage-clamp recordingsPrimary cortical neuronal culturesDendritic arbor growthNeuronal dendritic morphologyExcitatory synaptic functionCortical pyramidal neuronsExcitatory synapse numberCortical neuronal culturesExcitatory postsynaptic currentsAstrocyte-conditioned mediumPrimary cortical neuronsWild-type miceExcitatory synapse formationVoltage-clamp recordingsNovel therapeutic interventionsHuman neuropsychiatric disordersFatty acidsFatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1
Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Kishi H, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, Fujimoto T, Owada Y. Fatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1. Glia 2015, 63: 780-794. PMID: 25601031, DOI: 10.1002/glia.22784.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesCaveolaeCaveolin 1Cell SurvivalCells, CulturedCerebral CortexCholesterolCytokinesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGene Expression ProfilingGene Expression RegulationGlial Cell Line-Derived Neurotrophic FactorLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisSignal TransductionTransduction, GeneticConceptsLipid raft functionCaveolin-1Raft functionLipid raftsFatty Acid Binding Protein 7Function of caveolaeReceptor-mediated signal transductionMitogen-activated protein kinaseRole of FABP7Toll-like receptor 4Caveolin-1 expressionExtracellular stimuliCavin-1Protein bindsSignal transductionCaveolin-2Flotillin-1Protein kinaseReceptor alpha 1Transcriptional levelLong-chain fatty acidsLipid dynamicsWild-type astrocytesLipid homeostasisTLR4 recruitment
2014
Fatty Acid Binding Protein 3 Is Involved in n–3 and n–6 PUFA Transport in Mouse Trophoblasts
Islam A, Kagawa Y, Sharifi K, Ebrahimi M, Miyazaki H, Yasumoto Y, Kawamura S, Yamamoto Y, Sakaguti S, Sawada T, Tokuda N, Sugino N, Suzuki R, Owada Y. Fatty Acid Binding Protein 3 Is Involved in n–3 and n–6 PUFA Transport in Mouse Trophoblasts. Journal Of Nutrition 2014, 144: 1509-1516. PMID: 25122651, DOI: 10.3945/jn.114.197202.Peer-Reviewed Original ResearchConceptsWild-type micePlacental fatty acid transportFatty Acid Binding Protein 3Glucose uptakeLinoleic acidAdult metabolic diseaseBinding protein 3Fetal developmental disordersGene-ablated miceFA transportWild-type fetusesEmbryonic day 15.5Palmitic acidPlacental unitFatty acid transportMetabolic diseasesFetal developmentTrophoblast cellsBeWo cellsProtein 3Day 15.5MiceMouse placentaPlacentaMouse trophoblastFatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury
Miyazaki H, Sawada T, Kiyohira M, Yu Z, Nakamura K, Yasumoto Y, Kagawa Y, Ebrahimi M, Islam A, Sharifi K, Kawamura S, Kodama T, Yamamoto Y, Adachi Y, Tokuda N, Terai S, Sakaida I, Ishikawa T, Owada Y. Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury. American Journal Of Pathology 2014, 184: 2505-2515. PMID: 25041855, DOI: 10.1016/j.ajpath.2014.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCarbon TetrachlorideChemical and Drug Induced Liver InjuryCytokinesEnzyme-Linked Immunosorbent AssayFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFlow CytometryFluorescent Antibody TechniqueImmunohistochemistryIn Situ Nick-End LabelingKupffer CellsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsPhagocytosisReverse Transcriptase Polymerase Chain ReactionConceptsLiver injuryKupffer cellsKnockout miceLiver diseaseCytokine productionKC functionNumber of KCsKC phagocytic activityLiver injury processLiver necrotic areasChronic liver injurySerum liver enzymesWild-type miceNovel therapeutic approachesRole of FABP7Scavenger receptor CD36Cytokine expressionFibrogenic responseLiver enzymesInjury processPathological changesLiver cancerTherapeutic approachesReceptor CD36Tissue macrophages
2013
Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells
Sharifi K, Ebrahimi M, Kagawa Y, Islam A, Tuerxun T, Yasumoto Y, Hara T, Yamamoto Y, Miyazaki H, Tokuda N, Yoshikawa T, Owada Y. Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell And Tissue Research 2013, 354: 683-695. PMID: 24114376, DOI: 10.1007/s00441-013-1730-7.Peer-Reviewed Original ResearchConceptsLineage cellsOligodendrocyte lineage cellsOligodendrocyte progenitor cellsCultured oligodendrocyte progenitor cellsCell populationsOPCs/oligodendrocytesSignal transductionGene transcriptionKey intracellular moleculesOligodendrocyte lineage markersExpression of FABP5Differential expressionRegulatory roleIntracellular moleculesDifferentiation mediumFABP7FABP5FABP7 expressionLineage markersProgenitor cellsOligodendrocyte lineageMixed cortical culturesBrdU uptakeExpressionCentral role
2011
FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation
Sharifi K, Morihiro Y, Maekawa M, Yasumoto Y, Hoshi H, Adachi Y, Sawada T, Tokuda N, Kondo H, Yoshikawa T, Suzuki M, Owada Y. FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochemistry And Cell Biology 2011, 136: 501. PMID: 21938553, PMCID: PMC3192944, DOI: 10.1007/s00418-011-0865-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensAstrocytesCell ProliferationCells, CulturedCerebral CortexDisease Models, AnimalFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty Acids, Omega-3Gene ExpressionGliosisHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural Stem CellsOligodendrogliaProteoglycansWounds, StabConceptsFabp7 KO miceGlial cellsReactive gliosisFABP7 expressionBrain-type fatty acid-binding proteinProliferation of astrocytesExpression of FABP7Cellular fatty acid homeostasisWild-type miceGlial cell proliferationOligodendrocyte progenitor cellsWild-type astrocytesFatty acid-binding proteinRole of FABP7Fatty acid homeostasisFatty acid incorporationNeural stem cellsReactive astrocytesNormal cortexAstrocyte proliferationContralateral sideInjury modelAcid-binding proteinBrain pathologyBrain cortex