2021
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal Of Experimental Medicine 2021, 218: e20202135. PMID: 33433624, PMCID: PMC7808299, DOI: 10.1084/jem.20202135.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Central nervous systemSARS-CoV-2 neuroinvasionImmune cell infiltratesCOVID-19 patientsType I interferon responseMultiple organ systemsCOVID-19I interferon responseHuman brain organoidsNeuroinvasive capacityCNS infectionsCell infiltrateNeuronal infectionPathological featuresCortical neuronsRespiratory diseaseDirect infectionCerebrospinal fluidNervous systemMouse brainInterferon responseOrgan systemsHuman ACE2Infection
2013
Pathological features of highly invasive glioma stem cells in a mouse xenograft model
Sadahiro H, Yoshikawa K, Ideguchi M, Kajiwara K, Ishii A, Ikeda E, Owada Y, Yasumoto Y, Suzuki M. Pathological features of highly invasive glioma stem cells in a mouse xenograft model. Brain Tumor Pathology 2013, 31: 77-84. PMID: 23670138, DOI: 10.1007/s10014-013-0149-x.Peer-Reviewed Original ResearchConceptsGlioma stem cellsMouse xenograft modelSubventricular zoneXenograft modelCorpus callosumTumor xenograft modelMatrigel invasion assaysGSC linesInvasive potentialHigh invasive potentialStem cellsPathological featuresMultimodal therapyContralateral hemisphereTumor bulkMouse brainTumor progressionHuman glioblastomaMigratory propertiesMigration abilityCallosumCells