2018
FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region
Yamamoto Y, Kida H, Kagawa Y, Yasumoto Y, Miyazaki H, Islam A, Ogata M, Yanagawa Y, Mitsushima D, Fukunaga K, Owada Y. FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region. Journal Of Neuroscience 2018, 38: 10411-10423. PMID: 30341178, PMCID: PMC6596254, DOI: 10.1523/jneurosci.1285-18.2018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexHistone deacetylase 1KO miceCellular chaperonesFatty acid-binding proteinMethionine administrationTranscriptional repressor complexMouse anterior cingulate cortexGlutamic acid decarboxylase 67Promoter methylationEnzyme glutamic acid decarboxylase 67Emotional behaviorKO male miceGABAergic inhibitory interneuronsRepressor complexTranscriptional regulationSignal transductionAcid-binding proteinDNA methylationGene transcriptionMethyl-CpGIntracellular traffickingPromoter regionHuman psychiatric disordersPUFA homeostasis
2011
FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation
Sharifi K, Morihiro Y, Maekawa M, Yasumoto Y, Hoshi H, Adachi Y, Sawada T, Tokuda N, Kondo H, Yoshikawa T, Suzuki M, Owada Y. FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochemistry And Cell Biology 2011, 136: 501. PMID: 21938553, PMCID: PMC3192944, DOI: 10.1007/s00418-011-0865-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensAstrocytesCell ProliferationCells, CulturedCerebral CortexDisease Models, AnimalFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty Acids, Omega-3Gene ExpressionGliosisHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural Stem CellsOligodendrogliaProteoglycansWounds, StabConceptsFabp7 KO miceGlial cellsReactive gliosisFABP7 expressionBrain-type fatty acid-binding proteinProliferation of astrocytesExpression of FABP7Cellular fatty acid homeostasisWild-type miceGlial cell proliferationOligodendrocyte progenitor cellsWild-type astrocytesFatty acid-binding proteinRole of FABP7Fatty acid homeostasisFatty acid incorporationNeural stem cellsReactive astrocytesNormal cortexAstrocyte proliferationContralateral sideInjury modelAcid-binding proteinBrain pathologyBrain cortex