2018
Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells
Fligor C, Langer K, Sridhar A, Ren Y, Shields P, Edler M, Ohlemacher S, Sluch V, Zack D, Zhang C, Suter D, Meyer J. Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells. Scientific Reports 2018, 8: 14520. PMID: 30266927, PMCID: PMC6162218, DOI: 10.1038/s41598-018-32871-8.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRetinal organoidsAxonal outgrowthRGC developmentNeurite outgrowthExtensive axonal outgrowthRetinal ganglion cell developmentPost-synaptic targetsGanglion cell developmentStem cellsPluripotent stem cellsRGC layerThree-dimensional retinal organoidsGanglion cellsElaborate growth conesRGC differentiationHuman pluripotent stem cellsCellular replacementRetinal developmentGrowth factor signalingGrowth conesCell developmentOrganoidsFactor signalingGuidance receptors
2012
Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells
Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Cancer Biology & Therapy 2012, 13: 1214-1220. PMID: 22892842, PMCID: PMC3469479, DOI: 10.4161/cbt.21412.Peer-Reviewed Original ResearchConceptsPancreatic cancer cellsCancer cellsPolo-like kinase 1Human pancreatic cancer cellsChemotherapeutic drug gemcitabinePLK1 inhibitorsCombination index analysisKinase 1Pancreatic cancerClinical investigationTherapeutic targetCancer treatmentExpression levelsDrug gemcitabineValuable targetCellsTreatmentInhibitorsProliferationCritical roleCep70 promotes microtubule assembly in vitro by increasing microtubule elongation
Shi X, Wang J, Yang Y, Ren Y, Zhou J, Li D. Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. Acta Biochimica Et Biophysica Sinica 2012, 44: 450-454. PMID: 22427462, DOI: 10.1093/abbs/gms017.Peer-Reviewed Original ResearchConceptsCentrosomal proteinsMicrotubule assemblyMajor microtubule-organizing centerNovel centrosomal proteinDynamic cytoskeletal polymersMicrotubule-organizing centerMicrotubule elongationEukaryotic cellsMammalian cellsAnimal cellsMolecular detailsCep70Microtubule nucleationMolecular mechanismsCytoskeletal polymersMicrotubule lengthProteinMicrotubule numberAssemblyCellsCentrosomesElongationMicrotubulesGekko-sulfated Glycopeptide Inhibits Tumor Angiogenesis by Targeting Basic Fibroblast Growth Factor*
Zhang S, Zhu C, Ba Y, Chen D, Zhou X, Cao R, Wang L, Ren Y, Wu X. Gekko-sulfated Glycopeptide Inhibits Tumor Angiogenesis by Targeting Basic Fibroblast Growth Factor*. Journal Of Biological Chemistry 2012, 287: 13206-13215. PMID: 22371501, PMCID: PMC3340002, DOI: 10.1074/jbc.m111.321521.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularChick EmbryoChickensDrug DiscoveryDrugs, Chinese HerbalEarly Growth Response Protein 1Fibroblast Growth Factor 2GlucuronidaseHep G2 CellsHeparinHuman Umbilical Vein Endothelial CellsHumansLiver Neoplasms, ExperimentalMaleMiceMice, NudeNeovascularization, PathologicPolysaccharidesSurface Plasmon ResonanceXenograft Model Antitumor AssaysConceptsBasic fibroblast growth factorFibroblast growth factorTumor angiogenesisProduction of bFGFEndothelial cellsGrowth factorGekko swinhonis GuentherAbsence of bFGFInhibits tumor angiogenesisXenograft mouse modelLow-affinity receptorsEarly growth response 1Traditional Chinese medicineRelease of bFGFHeparan sulfateMouse modelTherapeutic targetHeparanase enzymatic activityTumor growthBFGF productionHeparin/heparan sulfateAffinity receptorInhibitory effectChinese medicineExtracellular matrixInhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration
Peng G, Ren Y, Sun X, Zhou J, Li D. Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Biochemical Pharmacology 2012, 83: 1374-1382. PMID: 22382068, DOI: 10.1016/j.bcp.2012.02.008.Peer-Reviewed Original ResearchConceptsEndothelial cellsCell migrationInhibition of farnesyltransferaseTherapeutic targetTumor cellsCancer treatmentEndothelial cell migrationUse of FTIsProtein 1Cancer therapyAngiogenesisPseudopodia formationInhibition of FTaseInhibitors of farnesyltransferaseInhibitionCellsLocalization of EB1Novel insightsPhysiological processesTherapyMicrotubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity
Sun X, Li D, Yang Y, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. Microtubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity. The Journal Of Pathology 2012, 226: 666-673. PMID: 21989536, DOI: 10.1002/path.3026.Peer-Reviewed Original ResearchConceptsBreast cancerPaclitaxel sensitivityPaclitaxel-containing chemotherapyActivity of paclitaxelBreast cancer correlatesCaspase-3 activity analysisBreast cancer cell linesBreast cancer cellsAbility of paclitaxelCancer cell linesCell proliferation assaysCancer correlatesPathological responsePaclitaxelProliferation assaysCell cycle progressionCancer cellsClinical samplesMitotic indexCell linesCancerMicrotubule-dependent mechanismCycle progressionDrug paclitaxelMicrotubule-binding protein
2011
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner
Li D, Xie S, Ren Y, Huo L, Gao J, Cui D, Liu M, Zhou J. Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2: 150-160. PMID: 21359602, PMCID: PMC4875255, DOI: 10.1007/s13238-011-1015-4.Peer-Reviewed Original ResearchConceptsHistone deacetylase 6Molecular mechanismsCell migrationEB1-dependent mannerEndothelial cell migrationCell motilityNovel playerCapillary-like structuresEndothelial cellsEndothelial tube formationNew capillary vesselsCell polarizationHDAC6 activityMicrotubule endsNew blood vesselsNovel insightsProtein 1Vascular endothelial cellsTube formationBlood vasculatureCapillary sproutingAngiogenic processChick embryosAngiogenesisImportant process