Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells
Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Cancer Biology & Therapy 2012, 13: 1214-1220. PMID: 22892842, PMCID: PMC3469479, DOI: 10.4161/cbt.21412.Peer-Reviewed Original ResearchConceptsPancreatic cancer cellsCancer cellsPolo-like kinase 1Human pancreatic cancer cellsChemotherapeutic drug gemcitabinePLK1 inhibitorsCombination index analysisKinase 1Pancreatic cancerClinical investigationTherapeutic targetCancer treatmentExpression levelsDrug gemcitabineValuable targetCellsTreatmentInhibitorsProliferationCritical roleCep70 promotes microtubule assembly in vitro by increasing microtubule elongation
Shi X, Wang J, Yang Y, Ren Y, Zhou J, Li D. Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. Acta Biochimica Et Biophysica Sinica 2012, 44: 450-454. PMID: 22427462, DOI: 10.1093/abbs/gms017.Peer-Reviewed Original ResearchMeSH KeywordsCell Cycle ProteinsCentrosomeHumansMicrotubule-Associated ProteinsMicrotubule-Organizing CenterMicrotubulesConceptsCentrosomal proteinsMicrotubule assemblyMajor microtubule-organizing centerNovel centrosomal proteinDynamic cytoskeletal polymersMicrotubule-organizing centerMicrotubule elongationEukaryotic cellsMammalian cellsAnimal cellsMolecular detailsCep70Microtubule nucleationMolecular mechanismsCytoskeletal polymersMicrotubule lengthProteinMicrotubule numberAssemblyCellsCentrosomesElongationMicrotubules