2024
Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies.
Long Y, Wang Y, Song Z, He X, He Y, Lin G. Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies. Toxins (Basel) 2024, 16 PMID: 39728796, DOI: 10.3390/toxins16120538.Peer-Reviewed Original ResearchEffects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response
Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024 PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsMicrobial biomarkersPredicting ICI responseGut microbiotaICI responseMulti-cancersEffects of gut microbiotaCheckpoint inhibitorsModulating CD8<sup>+</sup> T cells activityCD8<sup>+</sup> T cell activationICI respondersImmune checkpoint inhibitor recipientsPredictors of ICI responseImmune checkpoint inhibitor efficacyHungatella hathewayiCancer typesFecal metagenomesGut bacteriaSignature speciesT cell activationMicrobiota compositionF. prausnitziiPredicting therapeutic responseWilcoxon rank testMicrobiotaDEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility.
Jin J, Yim HCH, Chang HME, Wang Y, Choy KHK, Chan SY, Alqawasmeh OAM, Liao J, Jiang XT, Chan DYL, Fok EKL. DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility. PNAS Nexus 2024, 3: pgae419. PMID: 39359400, DOI: 10.1093/pnasnexus/pgae419.Peer-Reviewed Original ResearchSpatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.Peer-Reviewed Original ResearchCutaneous sarcoidosisNecrobiotic xanthogranulomaGranulomatous disorderGranuloma annulareNecrobiosis lipoidicaImmune activationMacrophage activationCutaneous granulomatous disordersPattern of immune activationType 2 immune activationActivation of Th1Pattern of Th1Alternative macrophage activationAlternative macrophage polarizationAlteration of extracellular matrixPatterns of macrophage activationCases of CSPredominant inflammationExtracellular matrix alterationsTh17 immunityT-helperTh2 polarizationIL-32Histological changesChemokine signalingSingle cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes
Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.Peer-Reviewed Original Research
2023
Single-cell transcriptome analysis reveals the effectiveness of cytokine priming irrespective of heterogeneity in mesenchymal stromal cells.
Wan Z, Chen YF, Pan Q, Wang Y, Yuan S, Chin HY, Wu HH, Lin WT, Cheng PY, Yang YJ, Wang YF, Kumta SM, Lee CW, Lee OK. Single-cell transcriptome analysis reveals the effectiveness of cytokine priming irrespective of heterogeneity in mesenchymal stromal cells. Cytotherapy 2023 PMID: 37715776, DOI: 10.1016/j.jcyt.2023.08.006.Peer-Reviewed Original ResearchDissecting the effects of METTL3 on alternative splicing in prostate cancer.
Wang L, Shi L, Liang Y, Ng JK, Yin CH, Wang L, Hou J, Wang Y, Fung CS, Chiu PK, Ng CF, Tsui SK. Dissecting the effects of METTL3 on alternative splicing in prostate cancer. Front Oncol 2023, 13: 1227016. PMID: 37675218, DOI: 10.3389/fonc.2023.1227016.Peer-Reviewed Original ResearchUnique Gut Microbiome Signatures among Adult Patients with Moderate to Severe Atopic Dermatitis in Southern Chinese.
Wang Y, Hou J, Tsui JC, Wang L, Zhou J, Chan UK, Lo CJY, Siu PLK, Loo SKF, Tsui SKW. Unique Gut Microbiome Signatures among Adult Patients with Moderate to Severe Atopic Dermatitis in Southern Chinese. Int J Mol Sci 2023, 24 PMID: 37629036, DOI: 10.3390/ijms241612856.Peer-Reviewed Original ResearchProteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responsesInvestigating causal relationships between the gut microbiota and allergic diseases: A mendelian randomization study.
Wang Y, Liu T, Wan Z, Wang L, Hou J, Shi M, Tsui SKW. Investigating causal relationships between the gut microbiota and allergic diseases: A mendelian randomization study. Front Genet 2023, 14: 1153847. PMID: 37124612, DOI: 10.3389/fgene.2023.1153847.Peer-Reviewed Original Research
2022
The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.
Liu T, Wang Y, Wang Y, Cheung SK, Or PM, Wong CW, Guan J, Li Z, Yang W, Tu Y, Wang J, Ho WL, Gu H, Cheng AS, Tsui SK, Chan AM. The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma. Cancer Lett 2022, 549: 215914. PMID: 36116740, DOI: 10.1016/j.canlet.2022.215914.Peer-Reviewed Original ResearchEffect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
Wang Y, Choy CT, Lin Y, Wang L, Hou J, Tsui JCC, Zhou J, Wong CH, Yim TK, Tsui WK, Chan UK, Siu PLK, Loo SKF, Tsui SKW. Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study. Biomedicines 2022, 10 PMID: 36428472, DOI: 10.3390/biomedicines10112904.Peer-Reviewed Original ResearchAltered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses.
Lin Y, Lau HC, Liu Y, Kang X, Wang Y, Ting NL, Kwong TN, Han J, Liu W, Liu C, She J, Wong SH, Sung JJ, Yu J. Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses. Gastroenterology 2022, 163: 908-921. PMID: 35724733, DOI: 10.1053/j.gastro.2022.06.038.Peer-Reviewed Original ResearchTemporal Dynamics of the Nasopharyngeal Microbiome and its Relationship with Childhood Asthma Exacerbation.
Hou J, Song Y, Leung ASY, Tang MF, Shi M, Wang EY, Tsun JGS, Chan RWY, Wong GWK, Tsui SK, Leung TF. Temporal Dynamics of the Nasopharyngeal Microbiome and its Relationship with Childhood Asthma Exacerbation. Microbiol Spectr 2022, 10: e0012922. PMID: 35546575, DOI: 10.1128/spectrum.00129-22.Peer-Reviewed Original Research
2021
Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice.
Wang Y, Zhang X, Li J, Zhang Y, Guo Y, Chang Q, Chen L, Wang Y, Wang S, Song Y, Zhao Y, Wang Z. Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice. Front Pharmacol 2021, 12: 609992. PMID: 33776762, DOI: 10.3389/fphar.2021.609992.Peer-Reviewed Original ResearchCharacterization of the gut microbiome in autism spectrum disorders and atopic dermatitis
Wang, Y. (2021). (Order No. 29186260). Available from ProQuest Dissertations & Theses Global. (2652957943). Retrieved from https://www.proquest.com/dissertations-theses/characterization-gut-microbiome-autism-spectrum/docview/2652957943/se-2Peer-Reviewed Original Research
2019
Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions.
Liu T, Wang Y, Wang Y, Chan AM. Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions. Cancers (Basel) 2019, 11 PMID: 31454965, DOI: 10.3390/cancers11091247.Peer-Reviewed Original Research