Investigating higher-order interactions in single-cell data with scHOT
Ghazanfar S, Lin Y, Su X, Lin D, Patrick E, Han Z, Marioni J, Yang J. Investigating higher-order interactions in single-cell data with scHOT. Nature Methods 2020, 17: 799-806. PMID: 32661426, PMCID: PMC7610653, DOI: 10.1038/s41592-020-0885-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsComputational BiologyDatabases, Nucleic AcidHepatocytesLiverMiceOligonucleotide Array Sequence AnalysisSequence Analysis, RNASingle-Cell AnalysisSoftwareConceptsSingle-cell dataCell fate choiceSingle-cell genomicsDifferential expression testingGene-gene correlationsFate choiceHigher-order interactionsKey genesTranscriptomic dataEmbryonic developmentCoordinated changesExpression testingGenesSubtle changesMouse liverMouse olfactory bulbCellsGenomicsSchotPseudotimeInteractionOlfactory bulbHigher-order measurementsCovariationVariability