2022
scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning
Lin Y, Wu T, Wan S, Yang J, Wong W, Wang Y. scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning. Nature Biotechnology 2022, 40: 703-710. PMID: 35058621, PMCID: PMC9186323, DOI: 10.1038/s41587-021-01161-6.Peer-Reviewed Original ResearchConceptsData modalitiesTransfer learning methodDifferent data modalitiesSingle-cell multiomics dataTransfer learningUnlabeled dataMultimodal datasetLeverage informationNeural networkLearning methodsData compositionLabel transferLabel accuracyJoint visualizationHeterogeneous collectionPromising resultsUnprecedented paceVisualizationFrameworkMultiomics dataScRNA-seq dataDatasetNetworkScATAC-seq dataCell atlases
2020
scClassify: sample size estimation and multiscale classification of cells using single and multiple reference
Lin Y, Cao Y, Kim H, Salim A, Speed T, Lin D, Yang P, Yang J. scClassify: sample size estimation and multiscale classification of cells using single and multiple reference. Molecular Systems Biology 2020, 16: msb199389. PMID: 32567229, PMCID: PMC7306901, DOI: 10.15252/msb.20199389.Peer-Reviewed Original ResearchConceptsType hierarchyKey computational challengeType identificationMultiple referencesType classification methodMultiscale classificationEnsemble learningCell type hierarchyClassification frameworkClassification methodPairs of referenceJoint classificationComputational challengesAccurate classificationLarge collectionTesting dataArt methodologiesDatasetLevel of complexityExperimental datasetsCell type identificationClassificationSingle-cell atlasesNovel applicationScalability