2020
Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection
Cui Y, Liu P, Mooney BP, Franz AWE. Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection. Journal Of Proteome Research 2020, 19: 2443-2456. PMID: 32375005, PMCID: PMC7419016, DOI: 10.1021/acs.jproteome.0c00173.Peer-Reviewed Original ResearchConceptsSerine-type endopeptidasesMetabolism related pathwaysQuantitative proteomic analysisFunctional enrichment analysisChikungunya virusRibosome biogenesisLabel-free quantificationRNA machineryNonpathogenic relationshipsNovel proteinProteome modulationProteomic analysisVesicular transportEnrichment analysisCHIKV infectionOxidative phosphorylationBiological pathwaysRelated pathwaysMass spectrometry dataPresence of CHIKVProteinMosquito samplesProteomeOral acquisitionMolecular interactions
2019
Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina
Cui Y, Grant DG, Lin J, Yu X, Franz AWE. Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina. Viruses 2019, 11: 1056. PMID: 31739432, PMCID: PMC6893695, DOI: 10.3390/v11111056.Peer-Reviewed Original ResearchConceptsZika virusMidgut basal laminaBasal laminaDengue 4 virusDissemination patternsSame mosquito speciesMeal ingestionZIKV infectionZIKV disseminationInfectious bloodmealHuman pathogenic virusesChikungunya virusInfected mosquitoesViral titersVirus disseminationMosquito midgutSalivary glandsFive daysBloodmeal digestionBloodmeal ingestionIngestionVirusMidgut infectionIncreased numberKey tissues