2022
Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease
Li E, Zheng Y, Cai M, Lai Q, Fang G, Du B, Shen C, Zhang Y, Wu L, Ding M. Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease. Epilepsia 2022, 63: 2173-2191. PMID: 35652436, DOI: 10.1111/epi.17315.Peer-Reviewed Original ResearchMeSH KeywordsAquaporin 4AutoantibodiesChildEpilepsyHumansMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaSeizuresConceptsMyelin oligodendrocyte glycoprotein antibody-associated diseaseAquaporin-4 antibody-positive neuromyelitis optica spectrum disorderNeuromyelitis optica spectrum disorderAntibody-associated diseaseMultiple sclerosisCentral nervous system inflammatory demyelinating diseaseAutoimmune-associated epilepsyCerebral cortical encephalitisConcomitant systemic infectionPresence of status epilepticusAcute disseminated encephalomyelitisInflammatory demyelinating diseaseSecondary to inflammationAcute symptomatic seizuresDrug-drug interactionsAQP4-NMOSDCortical encephalitisMultiple relapsesDisseminated encephalomyelitisImpact of treatmentStatus epilepticusDisease activitySymptomatic seizuresAntiseizure medicationsInflammatory mechanisms
2021
Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder Masquerading as Multiple Sclerosis: An Under-Recognized Entity?
Zheng Y, Cai M, Li E, Fang W, Shen C, Zhang Y. Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder Masquerading as Multiple Sclerosis: An Under-Recognized Entity? Frontiers In Immunology 2021, 12: 671425. PMID: 34220818, PMCID: PMC8249196, DOI: 10.3389/fimmu.2021.671425.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoproteinMultiple sclerosisMyelin oligodendrocyte glycoprotein-antibody testingClinical phenotypeConus medullaris involvementUnder-recognized entityProportion of patientsSteroid-dependentMedullary involvementOligodendrocyte glycoproteinMOGADRadiological manifestationsRecurrent episodesTherapeutic responseDisease courseAntibody seropositivityUnder-recognizedPatientsAntibody testMyelitisSclerosisSeropositivityMyelinManifestationsPhenotype
2020
IgG Index Revisited: Diagnostic Utility and Prognostic Value in Multiple Sclerosis
Zheng Y, Cai M, Yang F, Zhou J, Fang W, Shen C, Zhang Y, Ding M. IgG Index Revisited: Diagnostic Utility and Prognostic Value in Multiple Sclerosis. Frontiers In Immunology 2020, 11: 1799. PMID: 32973754, PMCID: PMC7468492, DOI: 10.3389/fimmu.2020.01799.Peer-Reviewed Original ResearchConceptsCohort of clinically isolated syndromeOligoclonal band positivityOligoclonal band statusOligoclonal bandsIgG indexPrognostic valueDiagnostic utilityMultiple sclerosisExpanded Disability Status Scale worseningAccurate diagnosis of multiple sclerosisMS diagnosisAttack of MSNegative oligoclonal bandsAsian populationsClinically isolated syndromeDiagnosis of multiple sclerosisElevated IgG indexEarly disease activityClinical relapseRetrospective studyDisease activityClinical challengeMS patientsAccurate diagnosisPredictive valueEvaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated disorder
Cai M, Zheng Y, Shen C, Yang F, Fang W, Zhang Y, Ding M. Evaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated disorder. Multiple Sclerosis Journal 2020, 27: 871-882. PMID: 32672091, DOI: 10.1177/1352458520939008.Peer-Reviewed Original ResearchMeSH KeywordsAquaporin 4AutoantibodiesBrainHumansMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaRetrospective StudiesSpinal CordConceptsMyelin oligodendrocyte glycoprotein antibody-associated disorderNeuromyelitis optica spectrum disorderLongitudinally extensive transverse myelitisDifferentiate neuromyelitis optica spectrum disordersDisease onsetMultiple sclerosisAQP4-ab-seropositive neuromyelitis optica spectrum disorderLongitudinally extensive transverse myelitis lesionsDiagnostic performanceChinese populationAntibody-associated disordersAQP4-Ab seropositivityExtensive transverse myelitisEvaluation of brainVentricle lesionsTransverse myelitisRetrospective studyImaging criteriaPeriventricular lesionsAquaporin-4Finger lesionsLesionsDiseaseOnsetDisorders