2023
Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1
Ding Y, Cen Z, Zheng Y, Qiu X, Ye Y, Chen X, Hu L, Wang B, Wang Z, Yin H, Shen C, Ming W, Ge Y, Xie F, Yang D, Ouyang Z, Wang H, Wu S, Ding M, Wang S, Luo W. Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1. Annals Of Clinical And Translational Neurology 2023, 11: 414-423. PMID: 38059543, PMCID: PMC10863925, DOI: 10.1002/acn3.51961.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesIED indexFamilial cortical myoclonic tremorCortical myoclonic tremorElectrophysiological featuresMyoclonic tremorGeneralized interictal epileptiform dischargesDistribution of interictal epileptiform dischargesFocal interictal epileptiform dischargesThirty-one patientsStage I-IIPositive family historyEpileptic seizuresCourse of epilepsySleep-wake cycleFCMTE patientsOvernight EEGProlonged prodromeBenign courseEpileptiform dischargesFamily historyChinese cohortPhotoparoxysmal responseGenetic testingSAMD12 geneExcitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Zheng Y, Xu C, Sun J, Ming W, Dai S, Shao Y, Qiu X, Li M, Shen C, Xu J, Fei F, Fang J, Jiang X, Zheng G, Hu W, Wang Y, Wang S, Ding M, Chen Z. Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia. Signal Transduction And Targeted Therapy 2023, 8: 186. PMID: 37193687, PMCID: PMC10188524, DOI: 10.1038/s41392-023-01404-9.Peer-Reviewed Original ResearchConceptsSomatostatin-positive interneuronsCortical dysplasiaSeizure networkDentate gyrusParvalbumin-positive interneuronsSomatostatin-positive neuronsExcitatory transmissionDysplastic lesionsSomatostatin interneuronsPoor prognosisSomatostatin-positiveEpileptic hippocampusImmunohistochemical studiesCalcium imagingDysplasiaInterneuronsElectrophysiological recordingsSeizure generalizationCellular basisSeizuresInhibitory roleHippocampusOptogenetic studiesDentateCellular substrates
2022
Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, Yang L, Fei F, Dai S, Chen L, Zheng Y, Xu C, Fang J, Wang S, Chen Z, Wang Y. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Reports 2022, 41: 111798. PMID: 36516780, DOI: 10.1016/j.celrep.2022.111798.Peer-Reviewed Original ResearchConceptsGeneralized seizuresActivity-dependent labeling techniquesInterictal periodSeizure developmentIP-enabledNeuronal ensemblesPiriform cortexPotential therapeutic targetCircuit rearrangementsOptogenetic activationHistological evidenceFocal seizuresIctal eventsSeizure generationControlling coherenceCellular mechanismsEpileptic networkSeizuresTherapeutic targetInterictal statePiriformSeizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease
Li E, Zheng Y, Cai M, Lai Q, Fang G, Du B, Shen C, Zhang Y, Wu L, Ding M. Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease. Epilepsia 2022, 63: 2173-2191. PMID: 35652436, DOI: 10.1111/epi.17315.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoprotein antibody-associated diseaseAquaporin-4 antibody-positive neuromyelitis optica spectrum disorderNeuromyelitis optica spectrum disorderAntibody-associated diseaseMultiple sclerosisCentral nervous system inflammatory demyelinating diseaseAutoimmune-associated epilepsyCerebral cortical encephalitisConcomitant systemic infectionPresence of status epilepticusAcute disseminated encephalomyelitisInflammatory demyelinating diseaseSecondary to inflammationAcute symptomatic seizuresDrug-drug interactionsAQP4-NMOSDCortical encephalitisMultiple relapsesDisseminated encephalomyelitisImpact of treatmentStatus epilepticusDisease activitySymptomatic seizuresAntiseizure medicationsInflammatory mechanisms
2020
Seizure occurrence in myelin oligodendrocyte glycoprotein antibody-associated disease: A systematic review and meta-analysis
Shen C, Zheng Y, Cai M, Yang F, Fang W, Zhang Y, Ding M. Seizure occurrence in myelin oligodendrocyte glycoprotein antibody-associated disease: A systematic review and meta-analysis. Multiple Sclerosis And Related Disorders 2020, 42: 102057. PMID: 32222694, DOI: 10.1016/j.msard.2020.102057.Peer-Reviewed Original ResearchConceptsMOG-Ab-associated diseaseAcute symptomatic seizuresSymptomatic seizuresMeta-analysisMyelin oligodendrocyte glycoprotein antibody-associated diseaseSystematic reviewMyelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated diseaseAntibody-associated diseaseSeizure occurrenceEpileptic seizuresProbability of seizure occurrenceProportion of childrenRandom-effects modelOccurrence of epileptic seizuresOccurrence of seizuresOccurrence of acute symptomatic seizuresClinical presentationMeta-analysis objectivePooled resultsInclusion criteriaPooled probabilitySeizuresDiseaseEffects modelPatients
2017
Active epilepsy prevalence, the treatment gap, and treatment gap risk profile in eastern China: A population-based study
Ding X, Zheng Y, Guo Y, Shen C, Wang S, Chen F, Yan S, Ding M. Active epilepsy prevalence, the treatment gap, and treatment gap risk profile in eastern China: A population-based study. Epilepsy & Behavior 2017, 78: 20-24. PMID: 29161630, DOI: 10.1016/j.yebeh.2017.10.020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnticonvulsantsChildChild, PreschoolChinaCross-Sectional StudiesEpilepsyFemaleHealth Services AccessibilityHealthcare DisparitiesHumansInfantInfant, NewbornInsurance, HealthMaleMiddle AgedPrevalenceRisk FactorsSeizuresSocioeconomic FactorsSurveys and QuestionnairesYoung AdultConceptsPrevalence of active epilepsyTreatment gapActive epilepsyCross-sectional population-based surveyLack of health insuranceActive epilepsy prevalencePopulation-based surveyMulti-stage cluster samplingPopulation-based studyRisk profileSeizure frequencyHealth insurance systemLogistic regression analysisEpilepsy prevalenceHealth insuranceAnalyze risk factorsAssociated with higher seizure frequencyCluster samplingReducing seizure frequencyRisk factorsHigher seizure frequencyInsurance systemRegression analysisAntiepileptic treatmentPrevalence