2022
Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase
Zhao J, Sun J, Zheng Y, Zheng Y, Shao Y, Li Y, Fei F, Xu C, Liu X, Wang S, Ruan Y, Liu J, Duan S, Chen Z, Wang Y. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nature Communications 2022, 13: 7136. PMID: 36414629, PMCID: PMC9681834, DOI: 10.1038/s41467-022-34662-2.Peer-Reviewed Original ResearchConceptsAnti-seizure effectsNa+-K+-ATPasePyramidal neuronsNeocortical seizuresRodent modelsInhibition of pyramidal neuronsExcitation-inhibition imbalanceTreatment of intractable epilepsyNa+-K+-ATPase activityMinimal side effectsAnti-seizure strategyAstrocyte-neuron interactionsOptogenetic activationTherapeutic windowIntractable epilepsyEpilepsy modelSide effectsCalcium signalingTherapeutic effectSeizuresActivity-dependentEpileptic seizuresAstrocyte stimulationAstrocytesPotential target
2020
HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window
Zhao J, Zheng Y, Liu K, Chen J, Lai N, Fei F, Shi J, Xu C, Wang S, Nishibori M, Wang Y, Chen Z. HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window. Neurotherapeutics 2020, 17: 710-721. PMID: 31802434, PMCID: PMC7283397, DOI: 10.1007/s13311-019-00815-3.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Anti-HMGB1 mAbStatus epilepticusTherapeutic targetLife-threatening neurological emergencyToll-like receptor 4 (TLR4)-dependent pathwayAnti-HMGB1 monoclonal antibodyNeutralization of HMGB1Plasma HMGB1 levelsMobility group box 1Severity of seizure activityExogenous high mobility group box 1Incidence of SENonrefractory SEHMGB1 levelsPredictive biomarkersTherapeutic responseNeurological emergencyTherapeutic windowBox 1Seizure activityMonoclonal antibodiesPharmacological therapeuticsSE periodEpilepticus