Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, Yang L, Fei F, Dai S, Chen L, Zheng Y, Xu C, Fang J, Wang S, Chen Z, Wang Y. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Reports 2022, 41: 111798. PMID: 36516780, DOI: 10.1016/j.celrep.2022.111798.Peer-Reviewed Original ResearchConceptsGeneralized seizuresActivity-dependent labeling techniquesInterictal periodSeizure developmentIP-enabledNeuronal ensemblesPiriform cortexPotential therapeutic targetCircuit rearrangementsOptogenetic activationHistological evidenceFocal seizuresIctal eventsSeizure generationControlling coherenceCellular mechanismsEpileptic networkSeizuresTherapeutic targetInterictal statePiriformActivated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase
Zhao J, Sun J, Zheng Y, Zheng Y, Shao Y, Li Y, Fei F, Xu C, Liu X, Wang S, Ruan Y, Liu J, Duan S, Chen Z, Wang Y. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nature Communications 2022, 13: 7136. PMID: 36414629, PMCID: PMC9681834, DOI: 10.1038/s41467-022-34662-2.Peer-Reviewed Original ResearchConceptsAnti-seizure effectsNa+-K+-ATPasePyramidal neuronsNeocortical seizuresRodent modelsInhibition of pyramidal neuronsExcitation-inhibition imbalanceTreatment of intractable epilepsyNa+-K+-ATPase activityMinimal side effectsAnti-seizure strategyAstrocyte-neuron interactionsOptogenetic activationTherapeutic windowIntractable epilepsyEpilepsy modelSide effectsCalcium signalingTherapeutic effectSeizuresActivity-dependentEpileptic seizuresAstrocyte stimulationAstrocytesPotential target