Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, Yang L, Fei F, Dai S, Chen L, Zheng Y, Xu C, Fang J, Wang S, Chen Z, Wang Y. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Reports 2022, 41: 111798. PMID: 36516780, DOI: 10.1016/j.celrep.2022.111798.Peer-Reviewed Original ResearchConceptsGeneralized seizuresActivity-dependent labeling techniquesInterictal periodSeizure developmentIP-enabledNeuronal ensemblesPiriform cortexPotential therapeutic targetCircuit rearrangementsOptogenetic activationHistological evidenceFocal seizuresIctal eventsSeizure generationControlling coherenceCellular mechanismsEpileptic networkSeizuresTherapeutic targetInterictal statePiriform