Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Zheng Y, Xu C, Sun J, Ming W, Dai S, Shao Y, Qiu X, Li M, Shen C, Xu J, Fei F, Fang J, Jiang X, Zheng G, Hu W, Wang Y, Wang S, Ding M, Chen Z. Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia. Signal Transduction And Targeted Therapy 2023, 8: 186. PMID: 37193687, PMCID: PMC10188524, DOI: 10.1038/s41392-023-01404-9.Peer-Reviewed Original ResearchConceptsSomatostatin-positive interneuronsCortical dysplasiaSeizure networkDentate gyrusParvalbumin-positive interneuronsSomatostatin-positive neuronsExcitatory transmissionDysplastic lesionsSomatostatin interneuronsPoor prognosisSomatostatin-positiveEpileptic hippocampusImmunohistochemical studiesCalcium imagingDysplasiaInterneuronsElectrophysiological recordingsSeizure generalizationCellular basisSeizuresInhibitory roleHippocampusOptogenetic studiesDentateCellular substrates