Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development
Yuan T, Wang Y, Jin Y, Yang H, Xu S, Zhang H, Chen Q, Li N, Ma X, Song H, Peng C, Geng Z, Dong J, Duan G, Sun Q, Yang Y, Yang F, Huang Z. Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. ELife 2024, 12: rp87559. PMID: 38289338, PMCID: PMC10942592, DOI: 10.7554/elife.87559.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticonvulsantsEpilepsyHomozygoteHumansMiceNAV1.6 Voltage-Gated Sodium ChannelNerve Tissue ProteinsQuinidineSodium