Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie International Edition 2023, 62: e202307020. PMID: 37920913, DOI: 10.1002/anie.202307020.Peer-Reviewed Original ResearchConceptsInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsImmune checkpoint blockade therapyInhibition of autophagyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyMetastatic tumorsAutophagy inhibitionTreatment modalities