Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors
Fang H, Zhang L, Wu Y, Chen L, Deng Z, Zheng Z, Wang Y, Yang Y, Chen Q. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chemical Engineering Journal 2024, 498: 155781. DOI: 10.1016/j.cej.2024.155781.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyImmunogenic cell deathDamage-associated molecular patternsPelvic tumorsIntraperitoneal chemotherapyGambogic acidAnti-tumor immune response in vivoInfiltration of cytotoxic T lymphocytesTriggering immunogenic cell deathRelease of damage-associated molecular patternsCancer cellsImmune responses in vivoCytotoxic T lymphocytesInduce apoptosis of cancer cellsApoptosis of cancer cellsResponses in vivoInhibitor of heat shock proteinCell deathHyperthermia-induced cell deathPenetration of nanoparticlesTumor extracellular matrixHeat shock proteinsOvarian cancerTumor microenvironmentT lymphocytes