A Highly Sensitive and Specific Non‐Invasive Test through Genome‐Wide 5‐Hydroxymethylation Mapping for Early Detection of Lung Cancer
Ren Y, Zhang Z, She Y, He Y, Li D, Shi Y, He C, Yang Y, Zhang W, Chen C. A Highly Sensitive and Specific Non‐Invasive Test through Genome‐Wide 5‐Hydroxymethylation Mapping for Early Detection of Lung Cancer. Small Methods 2023, 8: e2300747. PMID: 37990399, DOI: 10.1002/smtd.202300747.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerArea under the curveCell-free DNACell lung cancerBlood-based testLung cancerNon-small cell lung cancerLow-dose computed tomography screeningSmall cell lung cancerComputed tomography screeningCell-free DNA samplesEarly detection of lung cancerNon-invasive testsDetect cell-free DNADetection of lung cancerDetect lung cancerPulmonary nodulesSerum biomarkersDiagnostic accuracyHealthy controlsCancerTissue originLungEarly detectionPatients