2024
Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors
Fang H, Zhang L, Wu Y, Chen L, Deng Z, Zheng Z, Wang Y, Yang Y, Chen Q. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chemical Engineering Journal 2024, 498: 155781. DOI: 10.1016/j.cej.2024.155781.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyImmunogenic cell deathDamage-associated molecular patternsPelvic tumorsIntraperitoneal chemotherapyGambogic acidAnti-tumor immune response in vivoInfiltration of cytotoxic T lymphocytesTriggering immunogenic cell deathRelease of damage-associated molecular patternsCancer cellsImmune responses in vivoCytotoxic T lymphocytesInduce apoptosis of cancer cellsApoptosis of cancer cellsResponses in vivoInhibitor of heat shock proteinCell deathHyperthermia-induced cell deathPenetration of nanoparticlesTumor extracellular matrixHeat shock proteinsOvarian cancerTumor microenvironmentT lymphocytes
2023
Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie 2023, 135 DOI: 10.1002/ange.202307020.Peer-Reviewed Original ResearchInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsInhibition of autophagyImmune checkpoint blockade therapyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyAutophagy inhibitionMetastatic tumorsTreatment modalitiesMetal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie International Edition 2023, 62: e202307020. PMID: 37920913, DOI: 10.1002/anie.202307020.Peer-Reviewed Original ResearchConceptsInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsImmune checkpoint blockade therapyInhibition of autophagyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyMetastatic tumorsAutophagy inhibitionTreatment modalitiesA coordinative dendrimer-based nanovaccine for cancer treatment
Cao Z, Ren L, Niu L, Zhao R, Liu N, Zhuang Q, Pan F, Liu Z, Cheng Y, Yang Y, Chen Q. A coordinative dendrimer-based nanovaccine for cancer treatment. Matter 2023, 6: 3574-3597. DOI: 10.1016/j.matt.2023.08.001.Peer-Reviewed Original ResearchCancer vaccinesCancer immunotherapyDendritic cellsField of cancer immunotherapyTumor-specific immune responsesEffective cancer immunotherapyAnti-PD-L1Efficient antigen cross-presentationAntigen cross-presentationCGAS-STING pathwayCross-presentationImmune responseCancer cellsTherapeutic effectCancer treatmentCancerCGAS-STINGImmunotherapyVaccinePeptide carrierCellsNanovaccineNeoantigensPeptidePatients