2024
A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy
Miao Y, Niu L, Lv X, Zhang Q, Xiao Z, Ji Z, Chen L, Liu Y, Liu N, Zhu J, Yang Y, Chen Q. A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy. Advanced Materials 2024, 36: e2410715. PMID: 39210649, DOI: 10.1002/adma.202410715.Peer-Reviewed Original ResearchCancer immunotherapyMaturation of antigen-presenting cellsVaccine carriersImmune checkpoint blockade therapyAntigen-specific immune responsesInhibition of tumor growthCheckpoint blockade therapyEnhanced cancer immunotherapyAntigen-presenting cellsVaccine delivery technologiesB16-OVABlockade therapyImmune activationTumor modelTumor growthAntigen loadNanovaccineImmune responseMeticulous screeningAntigenic peptidesImmunostimulatory characteristicsChain ratioDelivery technologiesImmunotherapyIn vivo
2023
Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie 2023, 135 DOI: 10.1002/ange.202307020.Peer-Reviewed Original ResearchInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsInhibition of autophagyImmune checkpoint blockade therapyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyAutophagy inhibitionMetastatic tumorsTreatment modalitiesMetal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie International Edition 2023, 62: e202307020. PMID: 37920913, DOI: 10.1002/anie.202307020.Peer-Reviewed Original ResearchConceptsInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsImmune checkpoint blockade therapyInhibition of autophagyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyMetastatic tumorsAutophagy inhibitionTreatment modalities