Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries
Burns WR, Wang Y, Tang PC, Ranjbaran H, Iakimov A, Kim J, Cuffy M, Bai Y, Pober JS, Tellides G. Recruitment of CXCR3+ and CCR5+ T Cells and Production of Interferon-γ-Inducible Chemokines in Rejecting Human Arteries. American Journal Of Transplantation 2005, 5: 1226-1236. PMID: 15888026, DOI: 10.1111/j.1600-6143.2005.00892.x.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBlood VesselsCells, CulturedChemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL11Chemokine CXCL9Chemokines, CXCEndothelial CellsGraft RejectionHeart TransplantationHumansIntercellular Signaling Peptides and ProteinsInterferon-gammaLeukocytesMacrophage Inflammatory ProteinsMuscle, Smooth, VascularReceptors, CCR5Receptors, ChemokineReceptors, CXCR3Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesTransplantation, HomologousVascular DiseasesConceptsT cellsIFN-gamma-secreting T cellsClinical allograft rejectionRecruitment of CXCR3Allogeneic T cellsVascular smooth muscle cellsExpression of chemokinesCoronary artery segmentsProduction of interferonDifferent vascular compartmentsSmooth muscle cellsReal-time RT-PCRImmunodeficient mouse hostsAcute rejectionAllograft rejectionInducible chemokinesMicrovascular inflammationConduit arteriesIP-10MIP-1betaImmunological privilegeTh1 cellsChemokine mRNAChemokine receptorsI-TAC