CD2 is a Dominant Target for Allogeneic Responses
Bai Y, Fu S, Honig S, Wang Y, Qin L, Chen D, Bromberg JS. CD2 is a Dominant Target for Allogeneic Responses. American Journal Of Transplantation 2002, 2: 618-626. PMID: 12201362, DOI: 10.1034/j.1600-6143.2002.20706.x.Peer-Reviewed Original ResearchConceptsAlloantigen-driven proliferationIndefinite allograft survivalAntigen-presenting cellsT cellsAllograft survivalCardiac allograft recipientsProlong graft survivalT cell responsesCombination of mAbsIFN-gamma productionAllograft recipientsMAb administrationGraft survivalNK cytotoxicityAllograft rejectionCytokine responsesAllogeneic responseSurvival resultsPotent regulatory moleculesSingle MAbAnti-CD48B cellsMAbs resultsInhibitory mAbsMAbsL-Selectin-Dependent Lymphoid Occupancy Is Required to Induce Alloantigen-Specific Tolerance
Bai Y, Liu J, Wang Y, Honig S, Qin L, Boros P, Bromberg JS. L-Selectin-Dependent Lymphoid Occupancy Is Required to Induce Alloantigen-Specific Tolerance. The Journal Of Immunology 2002, 168: 1579-1589. PMID: 11823485, DOI: 10.4049/jimmunol.168.4.1579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell MovementCells, CulturedFingolimod HydrochlorideGraft SurvivalHeart TransplantationImmunosuppressive AgentsIsoantigensKineticsL-SelectinLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, KnockoutPropylene GlycolsSphingosineSpleenT-LymphocytesTransplantation ToleranceConceptsAlloantigen-specific toleranceIndefinite allograft survivalAllograft survivalLymph nodesT cellsLymph node homingSecondary lymphoid organsWild-type recipientsImmunosuppressive regimenPeripheral tolerizationCardiac allograftsAdoptive transferConcurrent administrationPeripheral bloodLymphoid organsLymphoid tissueHistologic examinationHoming receptorImmune regulationT lymphocytesTolerizationAg processingAlloantigensImmunosuppressantsLymphocytes