2014
Single nanoparticle detection using photonic crystal enhanced microscopy
Zhuo Y, Hu H, Chen W, Lu M, Tian L, Yu H, Long K, Chow E, King W, Singamaneni S, Cunningham B. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139: 1007-1015. PMID: 24432353, DOI: 10.1039/c3an02295a.Peer-Reviewed Original ResearchConceptsPhotonic crystalsResonance wavelengthMetal nanoparticlesSingle-nanoparticle imagingExperimental demonstrationReflection efficiencySpatial resolutionWavelengthBiosensor surfaceTime-domain computer simulationsNanoparticle detectionIndividual nanoparticlesReflection propertiesNanoparticlesCrystalLocal reductionMetalSurface attachmentReflection magnitudeBiosensorLocal shiftsComputer simulationsMoleculesBiosensingProtein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation
Zhuo Y, Tian L, Chen W, Yu H, Singamaneni S, Cunningham B. Protein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2014, 2014: 2069-2072. PMID: 25570391, DOI: 10.1109/embc.2014.6944023.Peer-Reviewed Original ResearchConceptsPhotonic crystalsLocalized surface plasmon resonance frequencyPC biosensorPhotonic crystal biosensorIndividual nanoparticlesSurface plasmon resonance frequencyPlasmon resonance frequencyResonance wavelengthExperimental demonstrationPresence of individual nanoparticlesBiosensing approachProtein-protein bindingBiosensorFunctionalized nanoparticlesNanoparticlesResonant frequencySurface adsorptionNanoparticle resolutionCrystalBinding detectionImaging approachResonanceFinite-differenceWavelength
2013
Photonic crystal enhanced microscopy for imaging of live cell adhesion
Chen W, Long K, Lu M, Chaudhery V, Yu H, Choi J, Polans J, Zhuo Y, Harley B, Cunningham B. Photonic crystal enhanced microscopy for imaging of live cell adhesion. Analyst 2013, 138: 5886-5894. PMID: 23971078, DOI: 10.1039/c3an01541f.Peer-Reviewed Original ResearchConceptsTime-resolved imagingPhotonic crystalsRelevant time-scalesTime-scalesDrug-induced apoptosisSubmicron resolutionSpatial resolutionMorphological signaturesStem cell differentiationCell-surface interactionsFilopodial extensionsPhotonsCell adhesionCell differentiationDynamic informationCell attachmentLiving cell adhesionMonitor cell behaviorCell behaviorBiological phenomenaResolutionApoptosisEvolutionChemotaxisLabel-free