2017
10 Noninvasive optical imaging of stem cell differentiation in biomaterials using photonic crystal surfaces
Choi J, Zhuo Y, Cunningham B, Harley B. 10 Noninvasive optical imaging of stem cell differentiation in biomaterials using photonic crystal surfaces. 2017, 195-207. DOI: 10.1016/b978-0-08-100603-0.00010-9.Peer-Reviewed Original ResearchPhotonic crystal surfacePlastic substratesStem cell differentiationReal timeImaging of stem cellsStem cell fate decisionsCell differentiationCell fate decisionsCell differentiation eventsLabel-free imaging of live cellsCells in vitroNoninvasive optical imagingCrystal surfacePopulations in situLiving cells in vitroSingle-cell levelPhotonic crystalsFate decisionsOrdinary glassSurfaceLabel-free imagingPool of cellsBioengineered platformCell growthPopulation of cells
2013
The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET
Liao X, Lu S, Wu Y, Xu W, Zhuo Y, Peng Q, Li B, Zhang L, Wang Y. The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET. PLOS ONE 2013, 8: e72233. PMID: 24015220, PMCID: PMC3754985, DOI: 10.1371/journal.pone.0072233.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedCSK Tyrosine-Protein KinaseEnzyme ActivationFeedback, PhysiologicalFluorescence Resonance Energy TransferFocal Adhesion Kinase 1HumansMesenchymal Stem CellsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsSignal TransductionSrc-Family KinasesTissue EngineeringConceptsSrc activationCell differentiationStem cell differentiationInhibiting FAK activityStages of stem cell differentiationPlasma membrane of human mesenchymal stem cellsSrc biosensorFAK activationActivated FAKActivated SrcFate decisionsInduction reagentsFAKSrc signalingKinase activityPlasma membraneSrcRegulation mechanismLiving human mesenchymal stem cellsUp-regulatedHuman mesenchymal stem cellsDifferentiation inductionNeural inductionDifferentiationCellsPhotonic crystal enhanced microscopy for imaging of live cell adhesion
Chen W, Long K, Lu M, Chaudhery V, Yu H, Choi J, Polans J, Zhuo Y, Harley B, Cunningham B. Photonic crystal enhanced microscopy for imaging of live cell adhesion. Analyst 2013, 138: 5886-5894. PMID: 23971078, DOI: 10.1039/c3an01541f.Peer-Reviewed Original ResearchConceptsTime-resolved imagingPhotonic crystalsRelevant time-scalesTime-scalesDrug-induced apoptosisSubmicron resolutionSpatial resolutionMorphological signaturesStem cell differentiationCell-surface interactionsFilopodial extensionsPhotonsCell adhesionCell differentiationDynamic informationCell attachmentLiving cell adhesionMonitor cell behaviorCell behaviorBiological phenomenaResolutionApoptosisEvolutionChemotaxisLabel-free