2015
Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review
Cunningham B, Zhang M, Zhuo Y, Kwon L, Race C. Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review. IEEE Sensors Journal 2015, 16: 3349-3366. PMID: 27642265, PMCID: PMC5021450, DOI: 10.1109/jsen.2015.2429738.Peer-Reviewed Original ResearchPhotonic crystal surfaceDetection of small moleculesCrystal surfaceAnalysis of drug-protein interactionsLabel-free high-resolution imagingDrug-protein interactionsDetection of disease biomarkersCancer biomarker detectionFluorescence enhancementLabel-free biosensingHigh-resolution imagesSmall moleculesOptical resonatorIndividual nanoparticlesBiomarker detectionPhotobleachable fluorescent dyesLife science researchDevice structureReview several recent advancesBiosensingDisease biomarkersHigh-resolution imaging of living cellsImaging of living cellsResolution imagesAnalysis of cells
2014
Single nanoparticle detection using photonic crystal enhanced microscopy
Zhuo Y, Hu H, Chen W, Lu M, Tian L, Yu H, Long K, Chow E, King W, Singamaneni S, Cunningham B. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139: 1007-1015. PMID: 24432353, DOI: 10.1039/c3an02295a.Peer-Reviewed Original ResearchConceptsPhotonic crystalsResonance wavelengthMetal nanoparticlesSingle-nanoparticle imagingExperimental demonstrationReflection efficiencySpatial resolutionWavelengthBiosensor surfaceTime-domain computer simulationsNanoparticle detectionIndividual nanoparticlesReflection propertiesNanoparticlesCrystalLocal reductionMetalSurface attachmentReflection magnitudeBiosensorLocal shiftsComputer simulationsMoleculesBiosensingProtein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation
Zhuo Y, Tian L, Chen W, Yu H, Singamaneni S, Cunningham B. Protein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2014, 2014: 2069-2072. PMID: 25570391, DOI: 10.1109/embc.2014.6944023.Peer-Reviewed Original ResearchConceptsPhotonic crystalsLocalized surface plasmon resonance frequencyPC biosensorPhotonic crystal biosensorIndividual nanoparticlesSurface plasmon resonance frequencyPlasmon resonance frequencyResonance wavelengthExperimental demonstrationPresence of individual nanoparticlesBiosensing approachProtein-protein bindingBiosensorFunctionalized nanoparticlesNanoparticlesResonant frequencySurface adsorptionNanoparticle resolutionCrystalBinding detectionImaging approachResonanceFinite-differenceWavelength