2023
Uncovering heterogeneous cardiometabolic risk profiles in US adults: the role of social and behavioral determinants of health
Ding Q, Lu Y, Herrin J, Zhang T, Marrero D. Uncovering heterogeneous cardiometabolic risk profiles in US adults: the role of social and behavioral determinants of health. BMJ Open Diabetes Research & Care 2023, 11: e003558. PMID: 37699720, PMCID: PMC10503393, DOI: 10.1136/bmjdrc-2023-003558.Peer-Reviewed Original ResearchConceptsCardiometabolic risk profileMetabolic risk factorsRace/ethnicityUndiagnosed diabetesUS adultsRisk factorsHealthcare accessNutrition Examination Survey 1999Risk profilePre-diabetes riskPrior diabetes diagnosisExamination Survey 1999Insurance coverageShort sleep durationLower diet qualityEffective prevention strategiesLimited healthcare accessBehavioral determinantsNon-white adultsMiddle-aged adultsHealth insurance coverageLow health insurance coverageCardiometabolic riskDiabetes statusDiabetes riskSex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study
Bikdeli B, Muriel A, Wang Y, Piazza G, Khairani C, Rosovsky R, Mehdipoor G, O'Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study. Seminars In Thrombosis And Hemostasis 2023, 49: 725-735. PMID: 36868268, DOI: 10.1055/s-0043-1764231.Peer-Reviewed Original ResearchConceptsOlder adultsClinical characteristicsRisk factorsElderly womenPE risk stratificationTransient provoking factorsRelevant clinical characteristicsSex differencesWarrants further investigationSex-related differencesSex-specific factorsClot burdenPE presentationChest painHormonal therapyHormone therapyPatient characteristicsPulmonary embolismYounger patientsAtherosclerotic diseaseRisk stratificationLung diseaseMedicare databaseProvoking factorsCardiovascular disease
2022
Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015
Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/circoutcomes.121.008535.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionInvasive strategyMyocardial infarctionHospital mortalityHospital outcomesMultivariable logistic regression modelCardiovascular risk factorsElevation myocardial infarctionSex-related disparitiesQuality of careProportion of womenLogistic regression modelsSex differencesClinical characteristicsClinical profileRisk factorsClinical covariatesSex-specific differencesPatientsInfarctionST segmentSex gapChinese hospitalsMortalityWomenSex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults
Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D’Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.Peer-Reviewed Original ResearchConceptsFirst acute myocardial infarctionAcute myocardial infarctionPsychosocial risk factorsRisk factor profilePopulation attributable fractionRisk factor associationsRisk factorsOdds ratioYoung womenAMI subtypesMyocardial infarctionPrevention of AMIType 1 acute myocardial infarctionFactor profileRisk of AMITraditional cardiovascular risk factorsSex-specific risk factorsFactor associationsYoung adultsRisk factor modificationCardiovascular risk factorsStrong associationNutrition Examination SurveyCase-control studyPopulation-based controlsDepression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.Peer-Reviewed Original ResearchConceptsSpontaneous coronary artery dissectionPatient Health Questionnaire-9Coronary artery dissectionPSS-14 scoreArtery dissectionBaseline PHQ-9 scoreAcute myocardial infarction patientsCardiovascular risk factorsPHQ-9 scoresAcute myocardial infarctionMyocardial infarction patientsYears of agePerceived Stress Scale scoresStress Scale scoresLinear mixed-effects analysisSCAD casesVIRGO StudyQuestionnaire-9Infarction patientsMixed-effects analysisMyocardial infarctionSubgroup analysisRisk factorsRoutine screeningClinical acuity
2016
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Zhou B, Bentham J, Di Cesare M, Bixby H, Danaei G, Cowan M, Paciorek C, Singh G, Hajifathalian K, Bennett J, Taddei C, Bilano V, Carrillo-Larco R, Djalalinia S, Khatibzadeh S, Lugero C, Peykari N, Zhang W, Lu Y, Stevens G, Riley L, Bovet P, Elliott P, Gu D, Ikeda N, Jackson R, Joffres M, Kengne A, Laatikainen T, Lam T, Laxmaiah A, Liu J, Miranda J, Mondo C, Neuhauser H, Sundström J, Smeeth L, Soric M, Woodward M, Ezzati M, Abarca-Gómez L, Abdeen Z, Rahim H, Abu-Rmeileh N, Acosta-Cazares B, Adams R, Aekplakorn W, Afsana K, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Ahrens W, Al Raddadi R, Al Woyatan R, Ali M, Alkerwi A, Aly E, Amouyel P, Amuzu A, Andersen L, Anderssen S, Ängquist L, Anjana R, Ansong D, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arlappa N, Aryal K, Arveiler D, Assah F, Assunção M, Avdicová M, Azevedo A, Azizi F, Babu B, Bahijri S, Balakrishna N, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros A, Barros M, Bata I, Batieha A, Baur L, Beaglehole R, Romdhane H, Benet M, Benson L, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bi Y, Bikbov M, Bjerregaard P, Bjertness E, Björkelund C, Blokstra A, Bo S, Bobak M, Boeing H, Boggia J, Boissonnet C, Bongard V, Braeckman L, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster L, Bruno G, Bueno-de-Mesquita H, Bugge A, Burns C, Bursztyn M, de León A, Cacciottolo J, Cameron C, Can G, Cândido A, Capuano V, Cardoso V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Dekkaki I, Chetrit A, Chiolero A, Chiou S, Chirita-Emandi A, Cho B, Cho Y, Chudek J, Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, Cruz J, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Dankner R, Dantoft T, Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Dehghan A, Delisle H, Deschamps V, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Dickerson T, Do H, Dobson A, Donfrancesco C, Donoso S, Döring A, Doua K, Drygas W, Dulskiene V, Džakula A, Dzerve V, Dziankowska-Zaborszczyk E, Eggertsen R, Ekelund U, El Ati J, Ellert U, Elliott P, Elosua R, Erasmus R, Erem C, Eriksen L, de la Peña J, Evans A, Faeh D, Fall C, Farzadfar F, Felix-Redondo F, Ferguson T, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Föger B, Foo L, Forslund A, Forsner M, Fortmann S, Fouad H, Francis D, Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Gavrila D, Geleijnse J, Ghasemian A, Ghimire A, Giampaoli S, Gianfagna F, Giovannelli J, Goldsmith R, Gonçalves H, Gross M, Rivas J, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Gregor R, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan O, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Gupta P, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Hadaegh F, Halkjær J, Hambleton I, Hardy R, Harikumar R, Hata J, Hayes A, He J, Hendriks M, Henriques A, Cadena L, Herrala S, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Dinc G, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Hu Y, Huerta J, Husseini A, Huybrechts I, Hwalla N, Iacoviello L, Iannone A, Ibrahim M, Ikram M, Irazola V, Islam M, Ivkovic V, Iwasaki M, Jackson R, Jacobs J, Jafar T, Jamrozik K, Janszky I, Jasienska G, Jelakovic B, Jiang C, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kamaruddin N, Kasaeian A, Katz J, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva G, Keil U, Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kemper H, Kengne A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khaw K, Kiechl S, Killewo J, Kim J, Klumbiene J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kristensen P, Krokstad S, Kromhout D, Kruger H, Kubinova R, Kuciene R, Kuh D, Kujala U, Kula K, Kulaga Z, Kumar R, Kurjata P, Kusuma Y, Kuulasmaa K, Kyobutungi C, Laatikainen T, Lachat C, Lam T, Landrove O, Lanska V, Lappas G, Larijani B, Laugsand L, Laxmaiah A, Bao K, Le T, Leclercq C, Lee J, Lee J, Lehtimäki T, Lekhraj R, León-Muñoz L, Levitt N, Li Y, Lilly C, Lim W, Lima-Costa M, Lin H, Lin X, Linneberg A, Lissner L, Litwin M, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Ma J, Machado-Coelho G, Machi S, Maggi S, Magliano D, Majer M, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Malyutina S, Manios Y, Mann J, Manzato E, Margozzini P, Marques-Vidal P, Marrugat J, Martorell R, Mathiesen E, Matijasevich A, Matsha T, Mbanya J, Posso A, McFarlane S, McGarvey S, McLachlan S, McLean R, McNulty B, Khir A, Mediene-Benchekor S, Medzioniene J, Meirhaeghe A, Meisinger C, Menezes A, Menon G, Meshram I, Metspalu A, Mi J, Mikkel K, Miller J, Miquel J, Mišigoj-Durakovic M, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Yusoff M, Møller N, Molnár D, Momenan A, Mondo C, Monyeki K, Moreira L, Morejon A, Moreno L, Morgan K, Moschonis G, Mossakowska M, Mostafa A, Mota J, Motlagh M, Motta J, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Musil V, Nagel G, Naidu B, Nakamura H, Námešná J, Nang E, Nangia V, Narake S, Navarrete-Muñoz E, Ndiaye N, Neal W, Nenko I, Nervi F, Nguyen N, Nguyen Q, Nieto-Martínez R, Niiranen T, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa O, Noorbala A, Noorbala T, Noto D, Al Nsour M, O'Reilly D, Oh K, Olinto M, Oliveira I, Omar M, Onat A, Ordunez P, Osmond C, Ostojic S, Otero J, Overvad K, Owusu-Dabo E, Paccaud F, Padez C, Pahomova E, Pajak A, Palli D, Palmieri L, Panda-Jonas S, Panza F, Papandreou D, Parnell W, Parsaeian M, Pecin I, Pednekar M, Peer N, Peeters P, Peixoto S, Pelletier C, Peltonen M, Pereira A, Pérez R, Peters A, Petkeviciene J, Pham S, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pitakaka F, Plans-Rubió P, Polakowska M, Polašek O, Porta M, Portegies M, Pourshams A, Pradeepa R, Prashant M, Price J, Puiu M, Punab M, Qasrawi R, Qorbani M, Radic I, Radisauskas R, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramos E, Rampal S, Reina D, Rasmussen F, Redon J, Reganit P, Ribeiro R, Riboli E, Rigo F, de Wit T, Ritti-Dias R, Robinson S, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez del Cristo M, Rodríguez-Villamizar L, Rojas-Martinez R, Rosengren A, Rubinstein A, Rui O, Ruiz-Betancourt B, Horimoto A, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Sakarya S, Salanave B, Salazar Martinez E, Salmerón D, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sans S, Santos D, Santos I, dos Santos R, Santos R, Saramies J, Sardinha L, Margolis G, Sarrafzadegan N, Saum K, Savva S, Scazufca M, Schargrodsky H, Schneider I, Schultsz C, Schutte A, Sen A, Senbanjo I, Sepanlou S, Sharma S, Shaw J, Shibuya K, Shin D, Shin Y, Siantar R, Sibai A, Silva D, Simon M, Simons J, Simons L, Sjöström M, Skovbjerg S, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Söderberg S, Solfrizzi V, Sonestedt E, Song Y, Sørensen T, Jérome C, Soumare A, Staessen J, Starc G, Stathopoulou M, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stronks K, Strufaldi M, Sun C, Sundström J, Sung Y, Suriyawongpaisal P, Sy R, Tai E, Tammesoo M, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Tarqui-Mamani C, Taylor A, Theobald H, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Tormo M, Torrent M, Traissac P, Trichopoulos D, Trichopoulou A, Trinh O, Trivedi A, Tshepo L, Tulloch-Reid M, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzourio C, Ueda P, Ugel E, Ulmer H, Uusitalo H, Valdivia G, Valvi D, van der Schouw Y, Van Herck K, van Rossem L, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren W, Verstraeten R, Victora C, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrdoljak A, Vrijheid M, Wade A, Wagner A, Walton J, Mohamud W, Wang M, Wang Q, Wang Y, Wannamethee S, Wareham N, Wedderkopp N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wijga A, Wilks R, Willeit J, Willeit P, Williams E, Wilsgaard T, Wojtyniak B, Wong T, Wong-McClure R, Woo J, Woodward M, Wu A, Wu F, Wu S, Xu H, Yan W, Yang X, Ye X, Yiallouros P, Yoshihara A, Younger-Coleman N, Yusoff A, Yusoff M, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhu D, Zimmermann E, Zuñiga Cisneros J. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. The Lancet 2016, 389: 37-55. PMID: 27863813, PMCID: PMC5220163, DOI: 10.1016/s0140-6736(16)31919-5.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureBlood pressure levelsSystolic blood pressureBlood pressureMean systolicMiddle-income countriesGlobal age-standardised prevalenceMean diastolic blood pressureMean systolic blood pressureHigher blood pressure levelsNumber of adultsAge-standardised prevalenceChronic kidney diseaseMean blood pressurePopulation-based studyAge-specific prevalenceImportant risk factorSaharan AfricaKidney diseasePooled analysisRisk factorsCardiovascular diseaseHigh-income countriesPrevalencePressure levelsSick Populations and Sick Subpopulations
Lu Y, Ezzati M, Rimm EB, Hajifathalian K, Ueda P, Danaei G. Sick Populations and Sick Subpopulations. Circulation 2016, 134: 472-485. PMID: 27324491, PMCID: PMC5001154, DOI: 10.1161/circulationaha.115.018102.Peer-Reviewed Original ResearchConceptsMultiple risk factorsCVD death ratesHigh-risk individualsRisk factorsNonfatal CVDCVD riskCVD deathFatal CVDDeath rateRisk-based interventionsWhite menCVD ratesNutrition Examination Survey 1999Cardiovascular disease death ratesWhite womenRacial disparitiesRisk of CVDExamination Survey 1999Black-white differencesDisease death ratesYears of ageBlack womenBlack menSick populationNational Health
2015
Mediators of the Effect of Body Mass Index on Coronary Heart Disease
Lu Y, Hajifathalian K, Rimm EB, Ezzati M, Danaei G. Mediators of the Effect of Body Mass Index on Coronary Heart Disease. Epidemiology 2015, 26: 153-162. PMID: 25643095, DOI: 10.1097/ede.0000000000000234.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseExcess relative riskHigh-sensitive C-reactive proteinHigher body mass indexC-reactive proteinBlood pressureRelative riskMass indexBlood glucoseHeart diseaseRisk factorsMetabolic risk factorsProspective cohort studyPrevalence of overweightMajor risk factorRandom-effects modelProthrombotic biomarkersCHD eventsCohort studyInflammatory biomarkersObese participantsMetabolic mediatorsMetabolic factorsMultiplicative scale
2013
The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A, Flaxman D, Foreman, Gabriel S, Gakidou E, Kassebaum N, Khatibzadeh S, Lim S, Lipshultz SE, London S, Lopez, MacIntyre MF, Mokdad AH, Moran A, Moran AE, Mozaffarian D, Murphy T, Naghavi M, Pope C, Roberts T, Salomon J, Schwebel DC, Shahraz S, Sleet DA, Murray, Abraham J, Ali MK, Atkinson C, Bartels DH, Bhalla K, Birbeck G, Burstein R, Chen H, Criqui MH, Dahodwala, Jarlais, Ding EL, Dorsey ER, Ebel BE, Ezzati M, Fahami, Flaxman S, Flaxman AD, Gonzalez-Medina D, Grant B, Hagan H, Hoffman H, Kassebaum N, Khatibzadeh S, Leasher JL, Lin J, Lipshultz SE, Lozano R, Lu Y, Mallinger L, McDermott MM, Micha R, Miller TR, Mokdad AA, Mokdad AH, Mozaffarian D, Naghavi M, Narayan KM, Omer SB, Pelizzari PM, Phillips D, Ranganathan D, Rivara FP, Roberts T, Sampson U, Sanman E, Sapkota A, Schwebel DC, Sharaz S, Shivakoti R, Singh GM, Singh D, Tavakkoli M, Towbin JA, Wilkinson JD, Zabetian A, Murray, Abraham J, Ali MK, Alvardo M, Atkinson C, Baddour LM, Benjamin EJ, Bhalla K, Birbeck G, Bolliger I, Burstein R, Carnahan E, Chou D, Chugh SS, Cohen A, Colson KE, Cooper LT, Couser W, Criqui MH, Dabhadkar KC, Dellavalle RP, Jarlais, Dicker D, Dorsey ER, Duber H, Ebel BE, Engell RE, Ezzati M, Felson DT, Finucane MM, Flaxman S, Flaxman AD, Fleming T, Foreman, Forouzanfar MH, Freedman G, Freeman MK, Gakidou E, Gillum RF, Gonzalez-Medina D, Gosselin R, Gutierrez HR, Hagan H, Havmoeller R, Hoffman H, Jacobsen KH, James SL, Jasrasaria R, Jayarman S, Johns N, Kassebaum N, Khatibzadeh S, Lan Q, Leasher JL, Lim S, Lipshultz SE, London S, Lopez, Lozano R, Lu Y, Mallinger L, Meltzer M, Mensah GA, Michaud C, Miller TR, Mock C, Moffitt TE, Mokdad AA, Mokdad AH, Moran A, Naghavi M, Narayan KM, Nelson RG, Olives C, Omer SB, Ortblad K, Ostro B, Pelizzari PM, Phillips D, Raju M, Razavi H, Ritz B, Roberts T, Sacco RL, Salomon J, Sampson U, Schwebel DC, Shahraz S, Shibuya K, Silberberg D, Singh JA, Steenland K, Taylor JA, Thurston GD, Vavilala MS, Vos T, Wagner GR, Weinstock MA, Weisskopf MG, Wulf S, Murray. The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors. JAMA 2013, 310: 591-606. PMID: 23842577, PMCID: PMC5436627, DOI: 10.1001/jama.2013.13805.Peer-Reviewed Original ResearchConceptsAge-standardized YLL rateHealthy life expectancyBurden of diseaseRisk factorsLife expectancyPopulation healthYLL ratesAge-standardized YLD rateChronic obstructive pulmonary diseaseHigher body mass indexAge-standardized death ratesDeath rateReference life expectancyRisk-outcome pairsSum of YLDsChronic kidney diseaseObstructive pulmonary diseaseHigh blood pressureIschemic heart diseaseBody mass indexLow back painDrug use disordersDisease 2010 studyMajor depressive disorderMajor health problem
2012
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa M, Amann M, Anderson H, Andrews K, Aryee M, Atkinson C, Bacchus L, Bahalim A, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell M, Blore J, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce N, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett R, Byers T, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen J, Cheng A, Child J, Cohen A, Colson K, Cowie B, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Jarlais D, Devries K, Dherani M, Ding E, Dorsey E, Driscoll T, Edmond K, Ali S, Engell R, Erwin P, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane M, Flaxman S, Fowkes F, Freedman G, Freeman M, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez H, Hall W, Hoek H, Hogan A, Hosgood H, Hoy D, Hu H, Hubbell B, Hutchings S, Ibeanusi S, Jacklyn G, Jasrasaria R, Jonas J, Kan H, Kanis J, Kassebaum N, Kawakami N, Khang Y, Khatibzadeh S, Khoo J, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher J, Leigh J, Li Y, Lin J, Lipshultz S, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Memish Z, Mensah G, Merriman T, Micha R, Michaud C, Mishra V, Hanafiah K, Mokdad A, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson P, Nolla J, Norman R, Olives C, Omer S, Orchard J, Osborne R, Ostro B, Page A, Pandey K, Parry C, Passmore E, Patra J, Pearce N, Pelizzari P, Petzold M, Phillips M, Pope D, Pope C, Powles J, Rao M, Razavi H, Rehfuess E, Rehm J, Ritz B, Rivara F, Roberts T, Robinson C, Rodriguez-Portales J, Romieu I, Room R, Rosenfeld L, Roy A, Rushton L, Salomon J, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh G, Sleet D, Smith E, Smith K, Stapelberg N, Steenland K, Stöckl H, Stovner L, Straif K, Straney L, Thurston G, Tran J, Van Dingenen R, van Donkelaar A, Veerman J, Vijayakumar L, Weintraub R, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams W, Wilson N, Woolf A, Yip P, Zielinski J, Lopez A, Murray C, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2224-2260. PMID: 23245609, PMCID: PMC4156511, DOI: 10.1016/s0140-6736(12)61766-8.Peer-Reviewed Original ResearchConceptsSecond-hand smokeDisease Study 2010High blood pressureRisk factorsDisease burdenGlobal disease burdenTobacco smokingRisk factor exposureBlood pressureGlobal DALYsChildhood underweightRelative riskGlobal burdenStudy 2010Unimproved waterCommunicable diseasesHigher body mass indexHigh-income North AmericaAlcohol useChildhood communicable diseasesDisability-adjusted life yearsRisk factor clustersDietary risk factorsCause-specific deathBody mass index