2016
The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/− Mice
Leng W, Ouyang X, Lei X, Wu M, Chen L, Wu Q, Deng W, Liang Z. The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/− Mice. Mediators Of Inflammation 2016, 2016: 6305735. PMID: 28104929, PMCID: PMC5220517, DOI: 10.1155/2016/6305735.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaApolipoproteins EAtherosclerosisBenzhydryl CompoundsBlood GlucoseBone MarrowDiabetes ComplicationsDiabetes Mellitus, ExperimentalGlucoseGlucosidesInflammasomesInterleukin-18Interleukin-1betaMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsConceptsEffect of dapagliflozinHigh-fat dietIL-1Dapagliflozin treatmentDiabetic atherosclerosisInhibitor dapagliflozinIL-18Reactive oxygen speciesSodium-glucose cotransporter 2 inhibitor dapagliflozinFat metabolismSGLT-2 inhibitor dapagliflozinCaspase-1 pathwayIndices of glucoseHematoxylin-eosin stainingStability of lesionsFormation of atherosclerosisNLRP3 protein levelsOil Red ODiabetic ApoEROS-NLRP3Aortic atherosclerosisMacrophage infiltrationNLRP3 inflammasomeTherapeutic effectMitochondrial reactive oxygen species
2014
Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice
Meng H, Wang Z, Wang W, Li W, Wu Q, Lei X, Ouyang X, Liang Z. Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice. Diabetes/Metabolism Research And Reviews 2014, 30: 457-466. PMID: 24827928, DOI: 10.1002/dmrr.2566.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCells, CulturedDiabetes Mellitus, ExperimentalFetal Stem CellsGreen Fluorescent ProteinsMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrovesselsNeovascularization, PhysiologicOsteopontinRandom AllocationRecombinant Fusion ProteinsSkinWound HealingWounds, PenetratingConceptsWT mesenchymal stem cellsMesenchymal stem cellsHealing timeNormal miceDiabetic miceSkin woundsBone marrow mesenchymal stem cell treatmentMesenchymal stem cell treatmentStem cellsWestern blottingHealing woundsKO male miceWild-type miceWounds of miceDiabetic skin woundsRole of osteopontinStem cell treatmentEffect of osteopontinExpression of osteopontinBacks of miceDiabetes mellitusIntraperitoneal injectionMale miceMicrovessel densityTail vein