Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
Ouyang X, Takahashi K, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells. Journal Of Pharmacological Sciences 2001, 87: 289-296. PMID: 11829148, DOI: 10.1254/jjp.87.289.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAnimals, NewbornBlotting, NorthernCardiomegalyCell CountCell SizeCell SurvivalCells, CulturedChromatography, High Pressure LiquidDNAMyocardiumPlant ExtractsPlant RootsRatsRats, WistarRNA, MessengerSalviaConceptsCultured neonatal rat cardiac cellsAng IIRat cardiac cellsNeonatal rat cardiac cellsCardiac cellsHypertrophic responseSalvia miltiorrhizaImmediate early response gene expressionAng II actionAng II stimulationChronotropic responsivenessAngiotensin IIMorphological injuryDose-dependent cytotoxicityII stimulationProtective effectEarly response gene expressionDifferent pharmacological activitiesEthyl acetate insoluble fractionResponse gene expressionTanshinone IIAHypertrophic growthPharmacological activitiesCardiomyocytesEffective constituents