2022
Annexin A2: The diversity of pathological effects in tumorigenesis and immune response
Huang Y, Jia M, Yang X, Han H, Hou G, Bi L, Yang Y, Zhang R, Zhao X, Peng C, Ouyang X. Annexin A2: The diversity of pathological effects in tumorigenesis and immune response. International Journal Of Cancer 2022, 151: 497-509. PMID: 35474212, DOI: 10.1002/ijc.34048.Peer-Reviewed Original ResearchMeSH KeywordsAnnexin A2Antibodies, AntinuclearCell Line, TumorCell Transformation, NeoplasticEpithelial-Mesenchymal TransitionHumansImmunityNeoplasmsNeovascularization, PathologicConceptsImmune responseAnnexin A2Pathological effectsToll-like receptor 2Anti-dsDNA antibodiesAcute promyelocytic leukemiaImmune host responseVariety of tumorsEpithelial-mesenchymal transitionInhibition of invasionTumor drug resistanceMultiple tumor cellsInflammatory factorsPathophysiologic processesG1-S phaseRetinal angiogenesisPromyelocytic leukemiaReceptor 2Production of plasminTumor cell invasionHost responseMultiple signal pathwaysNumerous malignanciesDrug resistanceTumor cells
2014
Immune Chaperone gp96 Drives the Contributions of Macrophages to Inflammatory Colon Tumorigenesis
Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, Zhang Y, Garret-Mayer E, Wu J, Liu B, Li Z. Immune Chaperone gp96 Drives the Contributions of Macrophages to Inflammatory Colon Tumorigenesis. Cancer Research 2014, 74: 446-459. PMID: 24322981, PMCID: PMC4002507, DOI: 10.1158/0008-5472.can-13-1677.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsCell Transformation, NeoplasticColitisColonColonic NeoplasmsCrosses, GeneticCytokinesDisease ProgressionDNA RepairGene DeletionGene Expression Regulation, NeoplasticInflammationInterleukin-17Interleukin-23MacrophagesMaleMembrane GlycoproteinsMiceMice, KnockoutMucous MembraneConceptsDNA repair machineryDNA repair pathwaysColon tumorigenesisTumor-associated macrophagesRepair machineryRepair pathwaysOncogenic programEndoplasmic reticulumMutation rateChaperone gp96Β-cateninColon cancerMechanistic underpinningsCellular sitesTumorigenesisReduced expressionEpithelial cellsGenotoxic natureToll-like receptorsInflammation-associated colon cancerImportant driverGp96Inflammation-associated colon tumorigenesisCritical inflammatory cytokinesExpression