AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19*
Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He JC, Abreu M, Unkeless JC, Mayer L, Xiong H. AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19*. Journal Of Biological Chemistry 2009, 284: 24006-24016. PMID: 19592489, PMCID: PMC2781995, DOI: 10.1074/jbc.m109.025528.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2AnimalsAutoimmune DiseasesCell LineDendritic CellsGene Expression RegulationInterleukin-10Interleukin-23 Subunit p19LipopolysaccharidesMacrophages, PeritonealMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase KinasesMutationMyeloid Differentiation Factor 88NF-kappa BProto-Oncogene Proteins c-junResponse ElementsToll-Like Receptor 4Transcription Factor AP-1ConceptsIL-23 p19Toll-like receptorsP19 expressionIL-10-deficient miceNF-kappaBMyD88-dependent Toll-like receptorIL-23 expressionRecombinant IL-10IL-12 familyC-JunWild-type miceAP-1 siteC-Fos bindsAP-1Promoter activationIL-23IL-10Dendritic cellsMyD88 pathwayAutoimmune diseasesImmune responseInflammatory signalsType miceLipopolysaccharide (LPS) stimulationNF-kappaB.