2021
The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2016
BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls.
Zhang XY, Chen da C, Tan YL, Tan S, Luo X, Zuo L, Soares JC. BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls. The Journal Of Clinical Psychiatry 2016, 77: e1011-8. PMID: 27561148, DOI: 10.4088/jcp.15m10269.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHealthy controlsCognitive functionBDNF gene variantsCase-control studyBDNF genetic variantsBDNF gene polymorphismPathogenesis of schizophreniaCognitive performanceRBANS total scoreHan Chinese populationBDNF polymorphismVal66Met polymorphismNeurotrophic factorBDNF geneGene polymorphismsCognitive impairmentPatientsPotential associationChinese populationNeuropsychological StatusHan Chinese individualsRepeatable BatterySchizophreniaTotal score
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individuals
2012
BDNF Val66Met Variant and Smoking in a Chinese Population
Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met Variant and Smoking in a Chinese Population. PLOS ONE 2012, 7: e53295. PMID: 23285275, PMCID: PMC3532294, DOI: 10.1371/journal.pone.0053295.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF Val66Met gene polymorphismBDNF Val66Met polymorphismSerum levelsVal66Met polymorphismGene polymorphismsChinese populationBDNF serum levelsSerum BDNF levelsVal/Val genotypeNumber of cigarettesHealthy male volunteersChinese male populationNicotine dependence scoresNeurotrophic factor familyBDNF Val66Met variantBDNF levelsNeurotrophic factorFagerstrom TestBDNF geneMale volunteersLarge cohortNicotine dependenceVal66Met variantNicotine addiction