2012
Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
Pei YF, Zhang L, Yang TL, Han Y, Hai R, Ran S, Tian Q, Shen H, Li J, Zhu XZ, Luo X, Deng HW. Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking. PLOS ONE 2012, 7: e30860. PMID: 22295116, PMCID: PMC3266269, DOI: 10.1371/journal.pone.0030860.Peer-Reviewed Original ResearchConceptsCopy number variantsAssociation studiesGenome-wide association studiesWide association studyGenotyping arraysAffymetrix SNP6.0Genetic mechanismsCNV regionsRelevant genesSusceptibility genesNumber variantsLTBP1GenesComplex disorderFGD4Cdc42Alcohol metabolismEnzymeSuggestive evidenceDownstreamMetabolismTGFB1ReceptorsVariantsPhysiological dependence
2006
Mutation screen of the GAD2 gene and association study of alcoholism in three populations
Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 144B: 183-192. PMID: 17034009, DOI: 10.1002/ajmg.b.30377.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanCase-Control StudiesDNA Mutational AnalysisExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic TestingGlutamate DecarboxylaseHispanic or LatinoHumansIsoenzymesLinkage DisequilibriumMaleMutationPolymorphism, Single NucleotideStudentsUnited StatesWhite PeopleConceptsSingle nucleotide polymorphismsGAD2 geneNon-synonymous polymorphismsAssociation studiesSequence variantsGamma-amino butyric acidGlutamate decarboxylase 2GenesMutation screenNucleotide polymorphismsAdditional populationsMajor enzymeG single nucleotide polymorphismPolymorphismG variantButyric acidPopulationVariantsEnzymeAdditional samplesRoleRussian malesVariationScreenDHPLC