2017
Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors
Wang J, Sun L, Cui W, Zhao W, Ma X, Li B, Liu Y, Yang Y, Hu Y, Huang L, Cheng X, Li L, Lu X, Tian Y, Yu Y. Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors. Journal Of Biological Chemistry 2017, 292: 7619-7635. PMID: 28302727, PMCID: PMC5418059, DOI: 10.1074/jbc.m116.771121.Peer-Reviewed Original ResearchHEK293 CellsHumansIon Channel GatingMolecular Dynamics SimulationProtein DomainsReceptors, Purinergic P2X4
2016
A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors*
Zhao W, Sun M, Sun L, Liu Y, Yang Y, Huang L, Fan Y, Cheng X, Cao P, Hu Y, Li L, Tian Y, Wang R, Yu Y. A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors*. Journal Of Biological Chemistry 2016, 291: 7990-8003. PMID: 26865631, PMCID: PMC4825005, DOI: 10.1074/jbc.m115.711127.Peer-Reviewed Original Research
2014
Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation
Zhao W, Wang J, Ma X, Yang Y, Liu Y, Huang L, Fan Y, Cheng X, Chen H, Wang R, Yu Y. Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation. Nature Communications 2014, 5: 4189. PMID: 24943126, DOI: 10.1038/ncomms5189.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAllosteric RegulationAmino Acid MotifsAnimalsHydrophobic and Hydrophilic InteractionsModels, MolecularProtein Structure, TertiaryRatsReceptors, Purinergic P2X4ConceptsAllosteric changesChannel gatingLeft flipperP2X4 receptorDorsal fin domainAllosteric eventsP2X4 receptor activationPhysiological functionsResidues leadFin domainHydrophobic interactionsEssential roleExtracellular ATPFundamental processesZinc bridgesChannel activationReceptor activationDorsal finP2X receptorsReceptorsGatingDomainActivationL217V291Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations
Huang L, Fan Y, Tian Y, Yang Y, Liu Y, Wang J, Zhao W, Zhou W, Cheng X, Cao P, Lu X, Yu Y. Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations. PLOS ONE 2014, 9: e97528. PMID: 24878662, PMCID: PMC4039465, DOI: 10.1371/journal.pone.0097528.Peer-Reviewed Original Research