2011
CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*
Bannister J, Thomas-Gatewood C, Neeb Z, Adebiyi A, Cheng X, Jaggar J. CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*. Journal Of Biological Chemistry 2011, 286: 15058-15066. PMID: 21357696, PMCID: PMC3083159, DOI: 10.1074/jbc.m110.182816.Peer-Reviewed Original ResearchConceptsArterial smooth muscle cellsSmooth muscle cellsMuscle cellsSurface expressionIntravascular pressureSmooth muscle-specific expressionArtery smooth muscle cellsDepolarization-induced vasoconstrictionHuman cerebral arteriesWhole-cell currentsReduced surface expressionLarge vasodilationCerebral arteryInflux pathwayVariety of stimuliCardiovascular systemFunctional surface expressionVasodilationProximal N-terminusReduced expressionMuscle-specific expressionE1CAuxiliary subunitsKnockdownPhysiological functions
2009
Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties
Cheng X, Pachuau J, Blaskova E, Asuncion-Chin M, Liu J, Dopico A, Jaggar J. Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties. AJP Heart And Circulatory Physiology 2009, 297: h680-h688. PMID: 19502562, PMCID: PMC2724194, DOI: 10.1152/ajpheart.00109.2009.Peer-Reviewed Original ResearchAlternative SplicingAmino Acid SequenceAnimalsBase SequenceCalcium Channels, L-TypeCells, CulturedCerebral ArteriesCerebrovascular CirculationExonsMolecular Sequence DataMuscle, Smooth, VascularMyocytes, Smooth MusclePatch-Clamp TechniquesProtein Structure, TertiaryRatsRats, Sprague-DawleyVascular Resistance
2007
A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*
Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister J, Dopico A, Jaggar J. A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*. Journal Of Biological Chemistry 2007, 282: 29211-29221. PMID: 17699517, PMCID: PMC2276565, DOI: 10.1074/jbc.m610623200.Peer-Reviewed Original ResearchConceptsExon 1cN-terminusExon 1bAuxiliary subunitsRich N-terminusCysteine-rich N-terminusNovel alternative splicingResistance-size cerebral arteriesPlasma membrane insertionExon 1Arterial myocytesMultiple vascular functionsIsoform-dependent differencesWhole-cell current densityN-terminal variantsAlternative splicingMembrane insertionChannel regulationExon 1AMolecular identityHuman diseasesSubunitsTerminusEntry pathwaySmooth muscle cells