Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018
Ji S, Qu Y, Sun Q, Zhao F, Qiu Y, Li Z, Li Y, Song H, Zhang M, Zhang W, Fu H, Cai J, Zhang Z, Zhu Y, Cao Z, Lv Y, Shi X. Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018. Environmental Science And Technology 2024, 58: 2693-2703. PMID: 38285630, DOI: 10.1021/acs.est.3c08718.Peer-Reviewed Original ResearchConceptsSerum alanine aminotransferaseLiver dysfunctionAlanine aminotransferaseNationwide cross-sectional studyRestricted cubic spline modelsGeneralized linear mixed modelsEffects of liver dysfunctionMediation analysisCross-sectional studyArsenic exposureAspartate aminotransferaseCubic spline modelsHuman biomonitoringAssociated with TADiabetes prevalenceChinese adultsLow-to-moderateLinear mixed modelsUrinary totalLowest quartileAlcohol consumptionLiver diseaseOverall populationDiabetesVitamin C Alleviates the Risk of Gestational Diabetes Mellitus Associated With Exposure to Metals
Wang Y, Wu W, Zhang P, Chen X, Feng Y, Yang H, Jin L, Huang H, Shi X, Wang S, Zhang Y. Vitamin C Alleviates the Risk of Gestational Diabetes Mellitus Associated With Exposure to Metals. Journal Of Diabetes Research 2024, 2024: 1298122. PMID: 39035682, PMCID: PMC11260216, DOI: 10.1155/2024/1298122.Peer-Reviewed Original ResearchConceptsRisk of gestational diabetes mellitusGestational diabetes mellitusVitamin C intakeDietary vitamin C intakeVitamin C supplement useExposure to heavy metalsHeavy metalsC intakeInductively coupled plasma mass spectrometryAssociated with increased risk of GDMGestational diabetes mellitus casesHigher dietary vitamin C intakeUnconditional logistic regression modelsAssociated with increased riskConcentrations of metalsLevels of mercuryExposure to metalsCase-control studyBlood levels of mercuryHigher blood levelsVitamin CVitamin C supplementationAssociated with metalsOxidative stress pathwaysEarly pregnancy