2021
Clinical effectiveness of DNA methyltransferase inhibitors and lenalidomide in older patients with refractory anemia with ring sideroblasts: a population-based study in the United States
Wang X, Zeidan AM, Wang R, Bewersdorf JP, Zhang C, Podoltsev NA, Huntington SF, Gore SD, Ma X. Clinical effectiveness of DNA methyltransferase inhibitors and lenalidomide in older patients with refractory anemia with ring sideroblasts: a population-based study in the United States. Leukemia & Lymphoma 2021, 62: 2438-2447. PMID: 33899659, DOI: 10.1080/10428194.2021.1913142.Peer-Reviewed Original ResearchConceptsPopulation-based studyDNA methyltransferase inhibitorRARS patientsRefractory anemiaRing sideroblastsRed blood cell transfusion independenceEnd Results-Medicare databaseLower-risk myelodysplastic syndromesPopulation-based cohortMethyltransferase inhibitorRBC-TIMedian durationMedian survivalOlder patientsTransfusion independenceTreatment initiationMyelodysplastic syndromeClinical effectivenessBetter survivalLenalidomideTreatment groupsPatientsRS statusOlder adultsAnemia
2016
Undertreatment of Patients (Pts) with Myelodysplastic Syndromes (MDS): Analysis of a Large Electronic Medical Records (EMR) Database Cohort of US Pts with MDS
Steensma D, Scott B, Ma X, Fliss A, Kiselev P, Swern A, Sugrue M. Undertreatment of Patients (Pts) with Myelodysplastic Syndromes (MDS): Analysis of a Large Electronic Medical Records (EMR) Database Cohort of US Pts with MDS. Blood 2016, 128: 4768. DOI: 10.1182/blood.v128.22.4768.4768.Peer-Reviewed Original ResearchAbsolute neutrophil countMedian absolute neutrophil countSequence of therapyMedian platelet countFirst therapyMedian ageMyelodysplastic syndromeMedian Hb levelPlatelet countHb levelsTreatment groupsCelgene CorporationSecond therapyFirst treatmentTreatment of MDSHigher absolute neutrophil countCommon initial therapyCurrent care patternsLower median hemoglobinUndertreatment of patientsAvailable therapeutic agentsHigher platelet countsClinical Modification codingSimilar Hb levelsThird therapy