2022
Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review
Zhao T, Alder N, Starkweather A, Chen M, Matson A, Xu W, Balsbaugh J, Cong X. Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review. Developmental Neuroscience 2022, 44: 438-454. PMID: 35995037, PMCID: PMC9928905, DOI: 10.1159/000526491.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInfantInfant, NewbornInfant, PrematureMitochondriaNeurodevelopmental DisordersPregnancyStress, PhysiologicalConceptsNeurodevelopmental outcomesPreterm infantsEarly life stressPostnatal stressSystematic reviewInfluence neurodevelopmental outcomesMitochondrial function/dysfunctionEarly lifeAssociated with stress exposurePreferred Reporting ItemsFull-termPrimary research articlesBIOSIS databasesInfluence of biological sexLife stressLack of longitudinal dataInfant stressInfantsReporting ItemsPretermInvasive samplingOutcomesStress exposureBehavioral changesFunction/dysfunction
2021
Multi-Omics Analysis on Neurodevelopment in Preterm Neonates
Casavant S, Chen J, Xu W, Lainwala S, Matson A, Chen M, Starkweather A, Maas K, Cong X. Multi-Omics Analysis on Neurodevelopment in Preterm Neonates. Nursing Research 2021, 70: 462-468. PMID: 34380978, PMCID: PMC8563389, DOI: 10.1097/nnr.0000000000000548.Peer-Reviewed Original ResearchConceptsPreterm infantsIntensive care unitNecrotizing enterocolitisFeeding intoleranceNeurodevelopmental impairmentNeonatal intensive care unit periodAdverse outcomesHost genetic variationIntestinal microbiomePreterm infants born <Care unitNeonatal intensive care unitInfants born <Weeks gestational ageGut microbiomeIntensive care unit periodFollow-up visitRegulation of intestinal healthPreterm neonatesGestational agePotential adverse outcomesNeurodevelopmental outcomesPain sensitivityPretermMulti-omics analysisPilot Study of Absolute Telomere Lengths in Preterm Infants
Casavant S, Li H, Reese B, Chen M, Cong X. Pilot Study of Absolute Telomere Lengths in Preterm Infants. Nursing Research 2021, 70: 481-486. PMID: 34173371, PMCID: PMC8563375, DOI: 10.1097/nnr.0000000000000535.Peer-Reviewed Original ResearchMeSH KeywordsFeeding BehaviorFemaleGrowth and DevelopmentHumansInfant, NewbornInfant, PrematureMaleNeurodevelopmental DisordersPainPilot ProjectsTelomereConceptsNeonatal intensive care unitPreterm infantsSample of preterm infantsAbsolute telomere lengthIncreased risk of neurodevelopmental disordersTelomere lengthAssociated with epigenetic alterationsRisk of neurodevelopmental disordersAssociated with painIntensive care unitPreterm infant samplesTime of dischargeBorn pretermInfant demographicsStudy of adultsAntibiotic usePretermPolymerase chain reactionPilot studyQuantitative polymerase chain reactionIncreased riskPainful proceduresShorter telomere lengthCare unitEpigenetic alterations
2019
Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review
Casavant S, Cong X, Moore J, Starkweather A. Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review. Early Human Development 2019, 131: 63-74. PMID: 30870624, DOI: 10.1016/j.earlhumdev.2019.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAngiomotinsBrain-Derived Neurotrophic FactorEpigenesis, GeneticHumansInfant, NewbornInfant, PrematureInsulin-Like Growth Factor IIIntensive Care Units, NeonatalIntercellular Signaling Peptides and ProteinsMembrane ProteinsMicrofilament ProteinsNeurodevelopmental DisordersNF-KappaB Inhibitor alphaReceptors, GlucocorticoidStress, PhysiologicalTacrolimus Binding ProteinsTelomereConceptsNeonatal intensive care unitPreterm infantsEpigenetic alterationsAssociated with increased riskLong-term outcome measuresTelomere erosionIntensive care unitBorn pretermTelomere lengthPreterm birthNeurodevelopmental outcomesPretermDisease entityPainful proceduresCare unitPreferred Reporting ItemsInfant stressHuman studiesLife-saving careTherapeutic interventionsOutcome measuresPsychiatric diseasesEarly detectionSystematic reviewReporting Items