2024
Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants
Zhao T, Chang X, Biswas S, Balsbaugh J, Liddle J, Chen M, Matson A, Alder N, Cong X. Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants. Developmental Neuroscience 2024, 46: 341-352. PMID: 38286121, PMCID: PMC11284246, DOI: 10.1159/000536509.Peer-Reviewed Original ResearchNeonatal intensive care unitPreterm premature rupture of membranesNICU Network Neurobehavioral ScalePost-menstrual ageNeurodevelopmental outcomesPreterm infantsNeurobehavioral outcomesNeonatal Intensive Care Unit Network Neurobehavioral ScaleNeonatal intensive care unit hospitalizationPremature rupture of membranesWeeks post-menstrual agePreterm premature ruptureRupture of membranesAssociated with neurobehavioral outcomesAssociated with protein levelsAdverse neurodevelopmental outcomesBuccal swabsOptimal neurodevelopmental outcomesProspective cohort studyIntensive care unitEvaluate protein expression levelsNeurobehavioral ScaleClinical characteristicsPretermMitochondrial function-related proteins
2023
The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2022
Trends of fecal calprotectin levels and associations with early life experience in preterm infants
Xu W, Zhang Y, Zhao W, Chen J, Maas K, Hussain N, Henderson W, Cong X. Trends of fecal calprotectin levels and associations with early life experience in preterm infants. Interdisciplinary Nursing Research 2022, 1: 36-42. PMID: 36590866, PMCID: PMC9766919, DOI: 10.1097/nr9.0000000000000006.Peer-Reviewed Original ResearchNeonatal intensive care unitFecal calprotectin levelsPreterm infantsMother's own milkFecal calprotectinFCP levelsFCP concentrationsNeonatal intensive care unit hospitalizationBiomarker of mucosal inflammationPainful proceduresMaturation of immune systemImmune systemChronic pain proceduresInfluence immune activationHigher severity of illness scoresNoninvasive surrogate biomarkerAcute painful proceduresPediatric gastrointestinal disordersSeverity of illness scoresImmature immune systemIntensive care unitChildren's medical centerNon-white raceNICU hospitalizationCalprotectin levelsSex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization
Chen J, Li H, Maas K, Starkweather A, Chen M, Cong X. Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization. Interdisciplinary Nursing Research 2022, 1: 6-13. PMID: 36590867, PMCID: PMC9766955, DOI: 10.1097/nr9.0000000000000004.Peer-Reviewed Original ResearchGut microbiome profilesNeonatal intensive care unitNeonatal intensive care unit hospitalizationMicrobiome profilesGut microbiotaPreterm infantsStool samplesComposition of gut microbiotaPredicted metabolic functionsPredictive functional profilingNeonatal gut microbiotaBacterial taxonomic compositionGut microbiota compositionAbundance of membranePreterm neonatesGlycan biosynthesisLipopolysaccharide biosynthesisNeonatal intensive care hospitalizationTaxonomic compositionGene regionB-diversityGut microbiomeMicrobiota compositionMale preterm neonatesDiversity index