2021
Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
Zuo S, Sun L, Wang Y, Chen B, Wang J, Ge X, Lu Y, Yang N, Shen P. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death & Disease 2021, 12: 208. PMID: 33627636, PMCID: PMC7904926, DOI: 10.1038/s41419-021-03499-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoatesCell LineageCoculture TechniquesGene Expression Regulation, LeukemicHumansHydrazinesJanus KinasesK562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudeMitogen-Activated Protein KinasesPyrazolesReceptors, ThrombopoietinSignal TransductionSTAT Transcription FactorsThrombopoiesisUmbilical CordXenograft Model Antitumor AssaysConceptsChronic myeloid leukemiaTyrosine kinase inhibitorsProgression of CMLCML cellsUC-MSCsDifferentiation therapyCurrent tyrosine kinase inhibitorsTherapeutic potentialMesenchymal stem cell treatmentAcute promyelocytic leukemia (APL) treatmentImmature white blood cellsSevere adverse effectsWhite blood cellsTrans retinoic acidStem cell treatmentStem/progenitor cellsComplete remissionTreatment regimenTumor burdenCML patientsCure rateMAPK signaling pathwaysPeripheral bloodHematopoietic stem/progenitor cellsMyeloid leukemia
2019
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization
Yang N, Tang Q, Qin W, Li Z, Wang D, Zhang W, Cao X, Lu Y, Ge X, Sun H, Shen P. Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization. EBioMedicine 2019, 45: 473-486. PMID: 31285187, PMCID: PMC6642413, DOI: 10.1016/j.ebiom.2019.06.053.Peer-Reviewed Original ResearchConceptsMacrophage polarizationAdipose inflammationObese miceMetabolic disordersObesity-related metabolic disordersHFD mouse modelObesity-related inflammationPro-inflammatory phenotypeHigh-fat dietPromising therapeutic strategyChemical small moleculesFatty acid oxidationChronic inflammationMagnetic cell sortingFat dietM1 polarizationM2 polarizationMetabolic dysfunctionMouse modelTherapeutic strategiesInflammationCDDO-MeCompound oleanolic acidInflammation treatmentHistological analysis