Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization
Yang N, Tang Q, Qin W, Li Z, Wang D, Zhang W, Cao X, Lu Y, Ge X, Sun H, Shen P. Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization. EBioMedicine 2019, 45: 473-486. PMID: 31285187, PMCID: PMC6642413, DOI: 10.1016/j.ebiom.2019.06.053.Peer-Reviewed Original ResearchConceptsMacrophage polarizationAdipose inflammationObese miceMetabolic disordersObesity-related metabolic disordersHFD mouse modelObesity-related inflammationPro-inflammatory phenotypeHigh-fat dietPromising therapeutic strategyChemical small moleculesFatty acid oxidationChronic inflammationMagnetic cell sortingFat dietM1 polarizationM2 polarizationMetabolic dysfunctionMouse modelTherapeutic strategiesInflammationCDDO-MeCompound oleanolic acidInflammation treatmentHistological analysis