Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity
Chen T, Chen Y, Hsu M, Liao Y, Wu C, Yao C, Yang W, Lin W, Lin Y. Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity. Journal Of Agricultural And Food Chemistry 2024, 72: 28294-28304. PMID: 39661093, DOI: 10.1021/acs.jafc.4c07659.Peer-Reviewed Original ResearchConceptsCalcium influxAntagonize N-methyl-D-aspartate receptorsExtracellular signal-regulated kinase signalingAlzheimer's diseaseN-methyl-D-aspartate receptorsImpairment of novel object recognitionNMDA-induced calcium influxMembrane potential sensitive dyeIntracellular calcium measurementsNovel object recognitionKinase signalingAMPA insultClinical therapeutic drugsPotential sensitive dyeERK phosphorylationGlutamatergic neuronsReceptor levelsCalcium measurementsMouse modelSpatial learning/memoryBehavioral testsTherapeutic drugsAnimal behaviorAbnormal depolarizationNatural compoundsTranscriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.)
Chen C, Lin C, Lu H, Liou C, Ho Y, Huang C, Zhang Z, Kao C, Yang W, Gong H. Transcriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.). BMC Genomics 2024, 25: 785. PMID: 39138417, PMCID: PMC11323441, DOI: 10.1186/s12864-024-10674-8.Peer-Reviewed Original ResearchConceptsGrowth performanceGut microbiotaB. pilosaAmino acid metabolismGrowth performance of tilapiaSignal transductionGut microbiota of fishMultifunctional feed additiveEnhanced growth performanceExpression of myogenic regulatory factorsPromote muscle growthMicrobiota of fishAmino acidsAcid metabolismComparative transcriptome analysisCarbohydrate metabolismMyogenic regulatory factorsWeeks of feedingComposition of gut bacteriaGut microbiome analysisMuscle growthKEGG enrichment resultsLipid metabolismGrowth-associated genesFunctional enrichment analysisFunctional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp
Lee Y, Umam K, Kuo T, Yang Y, Feng C, Yang W. Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp. Scientific Reports 2024, 14: 11584. PMID: 38773245, PMCID: PMC11109214, DOI: 10.1038/s41598-024-62436-x.Peer-Reviewed Original ResearchConceptsGrowth performanceWhiteleg shrimpV. parahaemolyticusDecreased feed conversion ratioFeed conversion ratioShrimp body weightInhibited V. parahaemolyticusRegulation of gut microbiotaRRNA sequence dataBacterial membrane destructionShrimp gutConversion ratioShrimp farmingSequence dataL. johnsoniiVibrio parahaemolyticusGut microbiotaVibriosisShrimpPathogenic bacteriaVibrioIn vitro regulationFunctional studiesFatty acidsBody weight