Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity
Chen T, Chen Y, Hsu M, Liao Y, Wu C, Yao C, Yang W, Lin W, Lin Y. Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity. Journal Of Agricultural And Food Chemistry 2024, 72: 28294-28304. PMID: 39661093, DOI: 10.1021/acs.jafc.4c07659.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsExtracellular Signal-Regulated MAP KinasesFlavanonesHumansMaleMiceNeuronsReceptors, N-Methyl-D-AspartateSignal TransductionConceptsCalcium influxAntagonize N-methyl-D-aspartate receptorsExtracellular signal-regulated kinase signalingAlzheimer's diseaseN-methyl-D-aspartate receptorsImpairment of novel object recognitionNMDA-induced calcium influxMembrane potential sensitive dyeIntracellular calcium measurementsNovel object recognitionKinase signalingAMPA insultClinical therapeutic drugsPotential sensitive dyeERK phosphorylationGlutamatergic neuronsReceptor levelsCalcium measurementsMouse modelSpatial learning/memoryBehavioral testsTherapeutic drugsAnimal behaviorAbnormal depolarizationNatural compounds