2012
Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1)
Yang W, Shen M, Jang Y, Chen Z, Chang C. Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1). The Journal Of Immunology 2012, 188: 72.1-72.1. DOI: 10.4049/jimmunol.188.supp.72.1.Peer-Reviewed Original ResearchType 1 diabetesC-C chemokine receptor type 5Chemokine receptor type 5Expression of CCR5Non-obese diabetic miceCXCR4-mediated chemotaxisCCR5 pathwayNOD micePhosphorylation of mitogen-activated protein kinasesCalcium mobilizationDose-dependentlyMitogen-activated protein kinaseProphylactic agentInflammatory diseasesInhibit CXCR4Cell lossDiabetic miceCCR5Anti-inflammatory compoundsType 5Leukocyte migrationPreventive effectT1DAbstract InflammationCXCR4
2011
Role of myeloid-derived suppressor cells in type 1 diabetes (167.16)
Yen C, Chen S, Pan P, Pan C, Yang W. Role of myeloid-derived suppressor cells in type 1 diabetes (167.16). The Journal Of Immunology 2011, 186: 167.16-167.16. DOI: 10.4049/jimmunol.186.supp.167.16.Peer-Reviewed Original ResearchMyeloid-derived suppressor cellsType 1 diabetesSuppressor cellsNOD/SCID miceT cellsMechanisms of action of MDSCsPresence of myeloid-derived suppressor cellsAutoimmune diseasesAutoimmune destruction of pancreatic isletsInduction of peripheral toleranceSuppression of T cell proliferationCD4+CD25+Foxp3+ TregsT cell suppressionDiabetic NOD miceInflammatory T cellsSingle-dose treatmentT cell proliferationAbstract Type 1 diabetesSuppress immune responsesDestruction of pancreatic isletsAnti-inflammation cytokinesSuppressed T1DAdoptive transferEffective immunotherapyPeripheral tolerance